Protein Info for B158DRAFT_2149 in Kangiella aquimarina DSM 16071

Annotation: Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 752 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details PF00930: DPPIV_N" amino acids 137 to 463 (327 residues), 334.7 bits, see alignment E=1.6e-103 PF07676: PD40" amino acids 156 to 184 (29 residues), 15.2 bits, see alignment (E = 5e-06) PF02129: Peptidase_S15" amino acids 509 to 657 (149 residues), 42.2 bits, see alignment E=2.5e-14 PF00326: Peptidase_S9" amino acids 557 to 752 (196 residues), 198.1 bits, see alignment E=4e-62 PF01738: DLH" amino acids 591 to 732 (142 residues), 26 bits, see alignment E=2e-09

Best Hits

Swiss-Prot: 48% identical to DAP4_PSEMX: Dipeptidyl aminopeptidase 4 (dap4) from Pseudoxanthomonas mexicana

KEGG orthology group: K01278, dipeptidyl-peptidase 4 [EC: 3.4.14.5] (inferred from 90% identity to kko:Kkor_0716)

Predicted SEED Role

"Dipeptidyl peptidase IV"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.14.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (752 amino acids)

>B158DRAFT_2149 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases (Kangiella aquimarina DSM 16071)
MKSKQFIHFLSIIPLLTGSFLTMTTAQANDNELGLTVERIYADPSLDGPELRKVKLSPDG
KRVTFLKGKVEEQERLDLWEYNLADGESRLLVDSNDLSPGEEQLSDEEKARRERMRLFAK
GIIDYYWGDDSQTLLFPLAGDIFVYDLSKDPKKATKQLTNTEAYETDIKLSPDGRFVSFI
RDQDIFKVEIATGKETQLTFDGEGAIKNGMAEFVAQEEMGRLTGYWWSPDSKKIAYLQVD
ESPVNIEKRYEINAEDFTVFEQRYPSTGTDNVLIKLGVLNLETGKTQWMDTGNETDIYIP
RVKWLADSSKVSYQWQSRDQQKLELRFADIKSGKAETILTESSDTWINLTKDLHFMKNQD
AFIWTSERSGFRHLYLYDLKGNLIRQLTNGDWVIDKVYGVDEESGVVYFDANKESPLQQD
LYAVSLNKVDEPKKITEKDGVHEVSFAKNMQIFVDYFSSVSQPKQVSLRNADGSLITWLE
ENTLNKNHPYYRYYQKASKPEFGTIKAEDGQEMYYRLYKPVPFDSSKQYPVIVDVYGGPH
AQRVRNQWGARNTYWHHLMASKGFIIFSLDNRGSWNRGKKFEDPIYKKLGDVEVKDQVAG
VEFLKSLPYVDEDKIGMFGWSYGGYMTIMSMFKEPDIFKVGVSVAPVTDWYLYDTHYTER
YLGHPESNAKGYEASNVFPYLNGLKGDLMIMHGMADDNVLFTNSTKLFKALQDANKPFDM
MNYPGSKHSIWGQKTRTHVFNTITKYFEENLK