Protein Info for B158DRAFT_1972 in Kangiella aquimarina DSM 16071

Annotation: copper-(or silver)-translocating P-type ATPase/heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 814 transmembrane" amino acids 186 to 206 (21 residues), see Phobius details amino acids 218 to 241 (24 residues), see Phobius details amino acids 253 to 273 (21 residues), see Phobius details amino acids 279 to 297 (19 residues), see Phobius details amino acids 433 to 453 (21 residues), see Phobius details amino acids 460 to 489 (30 residues), see Phobius details amino acids 762 to 779 (18 residues), see Phobius details amino acids 785 to 803 (19 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 8 to 84 (77 residues), 80.7 bits, see alignment E=2.7e-26 PF00403: HMA" amino acids 107 to 161 (55 residues), 39.3 bits, see alignment 1.7e-13 TIGR01511: copper-translocating P-type ATPase" amino acids 234 to 806 (573 residues), 460.9 bits, see alignment E=1.4e-141 TIGR01525: heavy metal translocating P-type ATPase" amino acids 253 to 805 (553 residues), 498 bits, see alignment E=8.8e-153 TIGR01512: cadmium-translocating P-type ATPase" amino acids 280 to 806 (527 residues), 349.2 bits, see alignment E=7.6e-108 TIGR01494: HAD ATPase, P-type, family IC" amino acids 287 to 782 (496 residues), 242.9 bits, see alignment E=1.1e-75 PF00122: E1-E2_ATPase" amino acids 323 to 489 (167 residues), 137.2 bits, see alignment E=1.1e-43 PF00702: Hydrolase" amino acids 513 to 717 (205 residues), 94.7 bits, see alignment E=2.5e-30 PF08282: Hydrolase_3" amino acids 690 to 738 (49 residues), 26.2 bits, see alignment 1.6e-09

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 86% identity to kko:Kkor_0540)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (814 amino acids)

>B158DRAFT_1972 copper-(or silver)-translocating P-type ATPase/heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase (Kangiella aquimarina DSM 16071)
MDAKVRSECFHCGLPVPANYHQTLEVLGKEREFCCVGCYSVAETIVSNGLTDYYQFRTEQ
AIRPDQELPPELVAFDEEDIQAEYRVSQPDSATTDQPSSIILLSESIRCSACAWLIERTL
RKISGVTGVQVNVAAQTINLQWQPESIELSKILKRLHQLGYAALPYKPEQALAINVKQQK
SWLRRLGLAGLGMMQVMMYAVGLYLGAWDDINQQHGHFLRLVSFLIATPVLFYAGFPFYF
SAIQSLRQLRLNMDVPITLALFLAYGASIWAVLTQSGEVYFDSVTMFVFFLLIGRYLEFR
ARQQVSEKVYKGQNSLPVYAERVNISETQGKMVSLKKLQQGDEILIRPGATVPIDGELIS
EQAEVNEAMLNGEFLPRQKLQGQMVMAGSVNTHQAIRLKVCGTLDNSYWAKLLSMQEAAL
LEKPRIGLLADTVARYFVLFILLLAATVAWYWLRHDPQEALWITLSVLVVSCPCALGLAT
PIAMTCGALAHNQRNVLIKGQHFLQNTSHITDVIFDKTGTLTEGAFVVDKVELFSEQSKQ
DVLAIIAALESQSEHPIAQAFYEYQNNEVTATDIKHHSFAGVSGSIKGDTFYFGNRQFIE
SCGAQFEQVESQSENSGLWLYDGQRLLAHVQLTDKVREQAKSMVMQLKSKGYRLHILSGD
PSEQTEHLAKQLGIQSWANGMTPEQKLSYVKSLQSTGARVMMVGDGLNDAPVMSAADSSV
AMAKASDLTRTTADSYLLSENLLDIPFILQKSRQTQSVIKQNISWALIYNAVMIPFAAMG
YIPPYLAAIGMSLSSIVVVVNSLKLKREQKQVVN