Protein Info for B158DRAFT_1690 in Kangiella aquimarina DSM 16071

Annotation: heavy metal efflux pump (cobalt-zinc-cadmium)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1042 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 338 to 358 (21 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 432 to 457 (26 residues), see Phobius details amino acids 477 to 498 (22 residues), see Phobius details amino acids 528 to 547 (20 residues), see Phobius details amino acids 865 to 884 (20 residues), see Phobius details amino acids 891 to 911 (21 residues), see Phobius details amino acids 917 to 941 (25 residues), see Phobius details amino acids 978 to 995 (18 residues), see Phobius details amino acids 1007 to 1033 (27 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1039 (1039 residues), 1265.4 bits, see alignment E=0 PF00873: ACR_tran" amino acids 5 to 1032 (1028 residues), 799.6 bits, see alignment E=2e-244

Best Hits

Swiss-Prot: 60% identical to CUSA_ECOLI: Cation efflux system protein CusA (cusA) from Escherichia coli (strain K12)

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 81% identity to alt:ambt_07220)

MetaCyc: 60% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1042 amino acids)

>B158DRAFT_1690 heavy metal efflux pump (cobalt-zinc-cadmium) (Kangiella aquimarina DSM 16071)
MIEGIIRWSVKNRFFVLLATLILAGIGGWSLKNTPVDAIPDLSDVQVIIKTNYPGQAPQV
VEDQVTYPLTTAMLSVPGAVTVRGYSFFGDSYVYVIFDEDTDAYWARSRVLEYLSQVAPT
LPSNAQPQLGPDATGVGWVYLYALVDRTGKHDISQLRSLQDWFLKYELQTVPGVSEVSAL
GGMVKQYQVKVHPDKLRAFNIPLSHIQMAIQRGNQEVGASVVEMAEAEYMVRASGYIQGK
EDLANIPLGLNVNGTPLLLKDVADITVGPQMRRGIAELNGEGEVVGGIVVMRFGENAQKT
IDGVKAKLDTLKNGLPEGVELVTVYDRSGLIERAVENLWYKLLEEFIVVALVCIAFLFHV
RSSLVAIVSLPVGILAAFIVMHAQGLNANIMSLGGIAIAIGAMIDGAIVMIENMHKHMER
TPLTKENRWQVVAESAAEVGPALFFSLLIITVSFVPVFTLEAQEGRMFSPLAFTKTYAMA
ASAALAVTLVPVLMGYFIRGKVLPEHKNPLNRALIAVYMPALRTVLHYPRSTLALAFIIT
VVGLWPVNKIGSEFIPPLDEGDLMYMPTTYPGLSIGKAREILQQTDKLIATVPEVKSVFG
KIGRAETATDPAPLTMIETFIQLKPRKEWREGMTTVKLKKELDALVKIPGLTNAWVMPIK
TRIDMLATGIKTPVGIKVAGPDLKEIEKIGRRLEQVLKDVLGTASVYSERVAGGRYIKVD
IQRDKAARYGLNIADVQQIVATAIGGMNVTQTIEGLERYPVNLRYPQDLRSSPEQLALLP
IVTESGQQIALADVANVYIEDGPPAIKSENARLNGWTFVDIDGVDIGSYVKNAMEVVEEQ
VDLPAGYSLNWSGQYEYMLRAKAKLTYVVPLTLAIIIILLYFNFRSFAEVAIIMGTLPLA
MVGSIWLMYLLGYNFSVAVGVGFIALAGVAVEISVIMLVYLNQAYRHMVDECKRQGVEPR
LETLRQAVLQGSGLRVRPVMMTAAAIIVGLLPIMYGTGTGSEVMSRIAAPMVGGMLSAVI
LTLLVLPVVYLLWRNPKEKQSK