Protein Info for B158DRAFT_1241 in Kangiella aquimarina DSM 16071

Annotation: dihydroorotase (EC 3.5.2.3)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00856: dihydroorotase, homodimeric type
  • amino acids 4 to 343 (340 residues), 478 bits, E=7.4e-148
• PF01979: Amidohydro_1
  • amino acids 11 to 310 (300 residues), 57.7 bits, E=1.2e-19
• PF04909: Amidohydro_2
  • amino acids 79 to 175 (97 residues), 39.2 bits, E=7.2e-14

Best Hits

Swiss-Prot: 66% identical to PYRC_ALIFM: Dihydroorotase (pyrC) from Aliivibrio fischeri (strain MJ11)

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 91% identity to kko:Kkor_1731)

MetaCyc: 54% identical to dihydroorotase (Escherichia coli K-12 substr. MG1655)
Dihydroorotase. [EC: 3.5.2.3]

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.3

Protein Sequence (346 amino acids)

>B158DRAFT_1241 dihydroorotase (EC 3.5.2.3) (Kangiella aquimarina DSM 16071)
MQSITITRPDDWHIHLRSGAALQHTVKDAARQFARAIVMPNLVPPVTNVEKAKDYRDCIL
RYKSDSTEFEPLMTLYLTDNTSVEDIEEAVASDFVKACKLYPAGATTNSDSGLTDIEKAY
PVFEKMAELGLPLLVHGEVTTPDIDVFDREKVFIDTKLKPVIEKFPNLKVVLEHITTKDA
VEFVRSQGPNVAATITVHHLLLNRNDMLVGGIRPHLYCLPILKRQIHQQALIEAATSGSP
KFFLGTDSAPHSKDKKENACGCAGVYTAYSAIELYAEVFESEGKLDKLEAFASFYGPDFY
GLPRNTETITLVKESWKMPKKLCLGNDTLVPFRAGETIEWKIKDNA