Protein Info for B158DRAFT_0910 in Kangiella aquimarina DSM 16071

Annotation: Glutamate dehydrogenase/leucine dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02812: ELFV_dehydrog_N
  • amino acids 33 to 160 (128 residues), 190.9 bits, E=6.8e-61
• PF00208: ELFV_dehydrog
  • amino acids 179 to 420 (242 residues), 240.5 bits, E=2.3e-75

Best Hits

Swiss-Prot: 51% identical to DHE4_SYNY3: NADP-specific glutamate dehydrogenase (gdhA) from Synechocystis sp. (strain PCC 6803 / Kazusa)

KEGG orthology group: K00262, glutamate dehydrogenase (NADP+) [EC: 1.4.1.4] (inferred from 96% identity to kko:Kkor_2077)

Predicted SEED Role

"NADP-specific glutamate dehydrogenase (EC 1.4.1.4)" in subsystem Arginine and Ornithine Degradation or Glutamate dehydrogenases or Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis or Proline Synthesis (EC 1.4.1.4)

MetaCyc Pathways

• L-glutamate biosynthesis III (1/1 steps found)
• L-glutamate and L-glutamine biosynthesis (5/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Glutamate metabolism
• Nitrogen metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.4

Protein Sequence (429 amino acids)

>B158DRAFT_0910 Glutamate dehydrogenase/leucine dehydrogenase (Kangiella aquimarina DSM 16071)
MSDQVYQDAITRVRRIGESAGVNNEVIEALMHPMRTMVASLPVRMDDGSTQYFTAYRCRY
NNALGPTKGGIRYHPDVNLQEVQALALWMTIKCAVVGLPYGGGKGGITVDPKKLSRMELE
RLSRSYVRQMADVISPDRDIPAPDVYTNERIMGWMMDEYEYITRKKAPGVITGKPLSLGG
SVGRDDATGRGAYLCILELEKKHNWKPEEITVAVQGFGNGGYHAARLLHDRGYKIVAISD
SRGGIFSSNGFDVPSIYKEKQATKQVKAVYCTHSVCEQVEHTAISNEELLELDVDILIPA
ALDGVIGGHNVDDIKAKYIVEVANGPVLSDVDDTLHNKGIHVIPDVLANAGGVTVSYFEW
VQNRSGYAWDLATVHERLEKIMSESFNRIWDLAHSEGRSMRNAAYTHAMRKIGEAIEAHG
TQDYFSMRD