Protein Info for B158DRAFT_0885 in Kangiella aquimarina DSM 16071

Annotation: excinuclease ABC, A subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 941 TIGR00630: excinuclease ABC subunit A" amino acids 4 to 925 (922 residues), 1509.8 bits, see alignment E=0 PF17760: UvrA_inter" amino acids 130 to 237 (108 residues), 130.3 bits, see alignment E=5.4e-42 PF17755: UvrA_DNA-bind" amino acids 291 to 400 (110 residues), 137 bits, see alignment E=6.1e-44

Best Hits

Swiss-Prot: 74% identical to UVRA_ECOL6: UvrABC system protein A (uvrA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03701, excinuclease ABC subunit A (inferred from 74% identity to aat:D11S_0457)

MetaCyc: 74% identical to UvrABC excision nuclease subunit A (Escherichia coli K-12 substr. MG1655)
3.1.25.-

Predicted SEED Role

"Excinuclease ABC subunit A" in subsystem DNA repair, UvrABC system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (941 amino acids)

>B158DRAFT_0885 excinuclease ABC, A subunit (Kangiella aquimarina DSM 16071)
MDNIDIRGAKTHNLKNIDLVLPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAY
ARQFLSLMEKPDVEHIEGLSPAISIEQKSTSHNPRSTVGTITEIYDYLRLLFARVGTPHC
PTHHLPLEAQTISQMVDHVLEQPEGTKLLLLAPVIKNRKGEHIQLLQELQAKGFVRARIN
GEVYDLSEAPTMELHKKHTIEVIVDRFKVKSDLQQRLAESFETALELSDGIARVAPMDED
SDLEEMVFSAKYACPTCGHSISELEPRIFSFNNPAGACPTCDGLGIDQFFDPDKIITNED
ISLAGGAIRGWDRRNVYYFHMLKSLAKHYKFDIEAPWSSLSKKIQDVVLYGSGKTQIDFE
YSNDRGDKYQRKHRFEGIIPNMQRRYHETESGAVREELQKYMTTQSCKACGGTRLNEDSR
NVFIDGTSLPQVTHWSIEQAHDYFSTLNLPGKRGEIASKVLKEIGERLSFLVNVGLDYLT
LERSADTLSGGEAQRIRLASQIGAGLVGVMYILDEPSIGLHQRDNDRLLQTLTHLRDLGN
TVIVVEHDEDAIRAADFIVDIGPGAGVHGGEIVAKGTLADIKKAKGSLTAQYLTGKLKIE
VPEKRTPVDAKKTIKVLGATGNNLNDVDLEIPVGLLTCITGVSGSGKSTLINDTLYPIVA
RDINRSSLQPKPYKEIQGLDNIDKVVDIDQSPIGRTPRSNPATYTGIFTPIRELFAGTQE
SRTRGYKPGRFSFNVKGGRCEACQGDGVIKVEMHFLPDVYVACDVCKGKRYNRETLEILY
KGKNINEVLDLTVEDAREFFDAIPAVARKLQTLIDVGLSYITLGQAATTLSGGEAQRVKL
SRELSKRDTGQTLYILDEPTTGLHFHDVNQLLKVLHRLRDHGNTVVVIEHNLDVIKTADW
IVDLGPEGGSKGGQIIATGTPEDVAKIKKSYTGKYLKPMLK