Protein Info for B158DRAFT_0635 in Kangiella aquimarina DSM 16071

Annotation: ATP-dependent metalloprotease FtsH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 641 transmembrane" amino acids 7 to 25 (19 residues), see Phobius details amino acids 104 to 125 (22 residues), see Phobius details PF06480: FtsH_ext" amino acids 8 to 98 (91 residues), 34.6 bits, see alignment E=5.5e-12 TIGR01241: ATP-dependent metallopeptidase HflB" amino acids 108 to 600 (493 residues), 794.6 bits, see alignment E=1.8e-243 PF06068: TIP49" amino acids 155 to 228 (74 residues), 26.9 bits, see alignment E=8e-10 PF07728: AAA_5" amino acids 194 to 316 (123 residues), 26.7 bits, see alignment E=1.5e-09 PF00004: AAA" amino acids 195 to 327 (133 residues), 161.1 bits, see alignment E=5.8e-51 PF17862: AAA_lid_3" amino acids 351 to 394 (44 residues), 47.1 bits, see alignment 4e-16 PF01434: Peptidase_M41" amino acids 408 to 599 (192 residues), 246.9 bits, see alignment E=4.6e-77

Best Hits

Swiss-Prot: 75% identical to FTSH_ECO57: ATP-dependent zinc metalloprotease FtsH (ftsH) from Escherichia coli O157:H7

KEGG orthology group: K03798, cell division protease FtsH [EC: 3.4.24.-] (inferred from 96% identity to kko:Kkor_2367)

MetaCyc: 75% identical to ATP-dependent zinc metalloprotease FtsH (Escherichia coli K-12 substr. MG1655)
3.4.24.-

Predicted SEED Role

"Cell division protein FtsH (EC 3.4.24.-)" in subsystem Bacterial Cell Division (EC 3.4.24.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (641 amino acids)

>B158DRAFT_0635 ATP-dependent metalloprotease FtsH (Kangiella aquimarina DSM 16071)
MNDLVKNILFWAVAAVILFIVIDAIQERQTDNSQVTFSEFVSRIEAKEVDDVVINPNNNL
VTGKDLNTNSEINAEIPAGGHEKLNDLLLANDINYSGKKREGGGFGTFLLSFGPILLLIA
VWIYFMRQMQGGGKGGGALSFGKSKARMLSEDQVKTTFADVAGVEEAKEEVGELVDFLRD
PRKFQRLGGKIPRGVLMVGPPGTGKTLLARAIAGEAKVPFFTISGSDFVEMFVGVGASRV
RDMFEQAKKHAPCIIFIDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFEGGEGVIV
IAATNRPDVLDPALLRPGRFDRQVVVGLPDIKGREQILKVHMRKVPIGDDVEPGVIARGT
PGFSGADLANLVNEAALFAARDNQRIVGMEQFEKAKDKILMGTERRSMVMTEEEKLNTAY
HEAGHAIVGLKVPSHDPVYKVSIIPRGRALGVTMYLPEQDKYSLSKEALESQLSSLFGGR
IAEEILNGPDKVTTGASNDIERATSLARNMVTKWGLSDKLGPLSYAEDEGEVFLGRSVTQ
HKNISDETARAIDAEIRDIIDRNYNRAKTILQDNMDKLHAMADALMKYETIDANQIKQIM
DGDDPSPPANWSDKKGPGGNGGSGPQPEAPKDSPVTEPSVD