Protein Info for Atu6090 in Agrobacterium fabrum C58

Annotation: ATP-dependent DNA ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 353 TIGR02779: DNA ligase D, ligase domain" amino acids 44 to 349 (306 residues), 331 bits, see alignment E=3.4e-103 PF01068: DNA_ligase_A_M" amino acids 56 to 233 (178 residues), 107.2 bits, see alignment E=9.4e-35 PF04679: DNA_ligase_A_C" amino acids 254 to 342 (89 residues), 87.6 bits, see alignment E=6.1e-29

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu6090)

Predicted SEED Role

"ATP-dependent DNA ligase (EC 6.5.1.1) LigC" in subsystem DNA Repair Base Excision (EC 6.5.1.1)

Isozymes

Compare fitness of predicted isozymes for: 6.5.1.1

Use Curated BLAST to search for 6.5.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CKW9 at UniProt or InterPro

Protein Sequence (353 amino acids)

>Atu6090 ATP-dependent DNA ligase (Agrobacterium fabrum C58)
MTRPPRSKPLLRDTEPPIRSKPRRKRNPAQPQLLFDPIPDRVEPALALLKAKPPTGNEWS
WELKWDGYRLAVHIEPQRIRILTRGGHDWTHRFPAIEQAARALGPATMIIDGEAVVLDDE
GRPDFGLLQQSLGASGKQAGRRASHAVLYAFDLVYLDGHDLRGVEYRSRRHLLEDTINGP
TNEASAIRISETLDAEPAVLLEHVCRLGLEGIVGKRLDQPYRSGRTGDWVKVKCIQSEAF
FIVGYERSASYPAGFGSLALAAYRDGDLVHVGSVGTGFKGAEIIRLRKILDTLRWKRKQP
PLPHSGTADIVWVQPTLIAEIEFRAWTSDGKLRHPSYKGLRERQDNADVYQLD