Protein Info for Atu4805 in Agrobacterium fabrum C58

Annotation: two component sensor kinase/response regulator hybrid

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 802 PF13596: PAS_10" amino acids 92 to 196 (105 residues), 78 bits, see alignment E=2.1e-25 PF00512: HisKA" amino acids 219 to 284 (66 residues), 41.3 bits, see alignment E=3.4e-14 PF02518: HATPase_c" amino acids 329 to 437 (109 residues), 81.4 bits, see alignment E=1.7e-26 PF00072: Response_reg" amino acids 466 to 578 (113 residues), 57.3 bits, see alignment E=4.3e-19 amino acids 609 to 716 (108 residues), 86.6 bits, see alignment E=3.3e-28 PF00196: GerE" amino acids 742 to 795 (54 residues), 50.9 bits, see alignment 2.3e-17

Best Hits

KEGG orthology group: K00575, chemotaxis protein methyltransferase CheR [EC: 2.1.1.80] (inferred from 100% identity to atu:Atu4805)

Predicted SEED Role

"Chemotaxis protein methyltransferase CheR (EC 2.1.1.80)" in subsystem Bacterial Chemotaxis (EC 2.1.1.80)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.80

Use Curated BLAST to search for 2.1.1.80

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CH56 at UniProt or InterPro

Protein Sequence (802 amino acids)

>Atu4805 two component sensor kinase/response regulator hybrid (Agrobacterium fabrum C58)
MAEGGDDSQKVPSAFEADTGPLPGSREAAHAKAFPSVGVGSSSSGLNAKDQSMNGELVTS
KEELQSLNEELTALNNQLHEALERQRAVANDLQNVLYSTDVPTLFLDSSLRIRFFTPATR
SVFHIVSSDVGRPLSDLSGFDGDGTLQTDAMATLHDGNTIDREIGGSDGRWYVRRVKPYR
GESKTVDGVVITFIDVSAQKQAAESREAAKKSAERATEAKSRFLSAASHDLRQPLQTLKL
LQGLLERSVGEGRARTFVQRMEETLSSMSGMLDSLLDINQIEAGMVEPQVVNFAIGNLLG
LLFKEFYYPARAAGLQLHVVPSSLAVRTDPRLFEQIVRNLLSNALKYTTSGKILVGCRRR
GTKVRFEVWDTGIGIPESQIEDVFQEYLQLDASAGTEDRGLGLGLSIVKRLSELLELRVA
VRSRLHKGSVFMIEIDQAPAGEPLVPLRAPVDGRPHHTTALSSASVLIIEDENGMRDLLK
MGLEQSGYVVAATSTGAEALAIVRGLQFKPDVILADYNFPTGGNGIAAIEDIRQALRRNV
PALILTGDISSKALTTFAQHEIPYLHKPVKLKDVVQVVETLVVRQTGERAEHISEPEDME
PMTGRLIEVVDDEKDIRDHLRALFEGEGWTVATYVSAEEYIADYKPDRSGCLLVDAYLPG
MVGMELLRLLKERQHRFPVIVITGHSDVRMAIDAMRYGAADFIEKPISYQELYRSVRSAL
DRSRDANEREERREAARATLATLTRKQRQILDRIVQGQANKIIAADLKLSQRTVENHRAS
IMRRTKSASLPALLRLVLNAEE