Protein Info for Atu4508 in Agrobacterium fabrum C58

Annotation: oxoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01408: GFO_IDH_MocA
  • amino acids 5 to 129 (125 residues), 92.5 bits, E=3.3e-30
• PF02894: GFO_IDH_MocA_C
  • amino acids 142 to 368 (227 residues), 56.8 bits, E=2.8e-19

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu4508)

Predicted SEED Role

"Myo-inositol 2-dehydrogenase (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

• myo-inositol degradation I (6/7 steps found)
• myo-, chiro- and scyllo-inositol degradation (6/10 steps found)
• myo-inositol degradation II (1/5 steps found)
• streptomycin biosynthesis (3/18 steps found)

KEGG Metabolic Maps

• Inositol phosphate metabolism
• Streptomycin biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

See A9CGR7 at UniProt or InterPro

Protein Sequence (375 amino acids)

>Atu4508 oxoreductase (Agrobacterium fabrum C58)
MAALGVGLIGTGYMGKCHALAWNNVTSVFGDVERPRLVTLAEVNPELAAKKAAKFGFARS
TGNWRDLLADPEIDVISVTTPNAFHPEMAIAALEAGKHVWCEKPMAPAFADAVKMRDAAR
RSAKAAAMGYNYIQNPVIRHIRRLIDEGAIGNVYHVRAEMDEDFMADATQPFYWKSEASS
GYGALDDFAVHPLSLLYALFGHAQSAITDMVKPYETRPLAGGGERAVETHDLASVLLKLE
GGISAVLIANRSAWGRKGRIAIQIYGSTGSILFDQERMNEFQLYTTDGRPEEQGFRTILT
APHHKPYDRFIPAPGHGLGFNDLKVIECRELIAAIDGNKAHIIDFEEGLKIERSIHAMAR
SFAEGRWVRAEEIAE