Protein Info for Atu4488 in Agrobacterium fabrum C58

Annotation: ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 222 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 56 to 79 (24 residues), see Phobius details amino acids 86 to 108 (23 residues), see Phobius details amino acids 147 to 169 (23 residues), see Phobius details amino acids 189 to 208 (20 residues), see Phobius details PF00528: BPD_transp_1" amino acids 32 to 221 (190 residues), 78.3 bits, see alignment E=3.2e-26

Best Hits

Swiss-Prot: 57% identical to METI_VIBCH: Probable D-methionine transport system permease protein MetI (metI) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02072, D-methionine transport system permease protein (inferred from 100% identity to atu:Atu4488)

MetaCyc: 54% identical to L-methionine/D-methionine ABC transporter membrane subunit (Escherichia coli K-12 substr. MG1655)
RXN0-4522 [EC: 7.4.2.11]; 7.4.2.11 [EC: 7.4.2.11]; TRANS-RXN-383 [EC: 7.4.2.11]; TRANS-RXN0-510 [EC: 7.4.2.11]; TRANS-RXN0-511 [EC: 7.4.2.11]

Predicted SEED Role

"Methionine ABC transporter permease protein" in subsystem Methionine Biosynthesis or Methionine Degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.11

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CGQ8 at UniProt or InterPro

Protein Sequence (222 amino acids)

>Atu4488 ABC transporter permease (Agrobacterium fabrum C58)
MSPDMIFNLLFKGLWQTLHMVAVAGIVGSIIGVPMGVFLATSGKGELFPAPMTNRILGLI
VNAARSTPFIILVVAIIPFTRLVAGTSIGTSAAIVPLTVATVPFIARLVEAAIREVDKGL
IEAARAMGATPLQIVTKVLLAEAKPGITLALTLTLVSLIGYSAMVGAVGGGGLGDLGIRY
GYQRFMPDVMLAVVLVLIVLVQLVQSAGDRLARSFDKRTRKN