Protein Info for Atu4479 in Agrobacterium fabrum C58

Annotation: MFS permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 527 transmembrane" amino acids 24 to 46 (23 residues), see Phobius details amino acids 63 to 84 (22 residues), see Phobius details amino acids 91 to 111 (21 residues), see Phobius details amino acids 117 to 142 (26 residues), see Phobius details amino acids 149 to 172 (24 residues), see Phobius details amino acids 178 to 201 (24 residues), see Phobius details amino acids 213 to 232 (20 residues), see Phobius details amino acids 245 to 264 (20 residues), see Phobius details amino acids 284 to 303 (20 residues), see Phobius details amino acids 315 to 335 (21 residues), see Phobius details amino acids 347 to 367 (21 residues), see Phobius details amino acids 380 to 400 (21 residues), see Phobius details amino acids 416 to 431 (16 residues), see Phobius details amino acids 488 to 514 (27 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 24 to 508 (485 residues), 453.8 bits, see alignment E=3.7e-140 PF07690: MFS_1" amino acids 31 to 424 (394 residues), 161.1 bits, see alignment E=1.9e-51

Best Hits

Swiss-Prot: 42% identical to EMRB_ACIBT: Colistin resistance protein EmrB (emrB) from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377)

KEGG orthology group: None (inferred from 100% identity to atu:Atu4479)

Predicted SEED Role

"Inner membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CGQ5 at UniProt or InterPro

Protein Sequence (527 amino acids)

>Atu4479 MFS permease (Agrobacterium fabrum C58)
MAATVVGTGGASIPVDPPMDRRRLIAFFAMVFGMFMSILDIQIVSASLAEIQAGLGAGSD
EIAWVQTSYLIAEVIMIPLSGTLARILSTRVLFATCAAGFTLSSALCATATNIDQMIVYR
AIQGFIGGGMIPSVFAAAFTIFPPSKRSVVSPIIGLVATLAPTIGPTVGGYLSNAFSWHW
LFLVNIIPGIIVTILTWSLIDFDKPETSLWKKFDWWGLISMAVFLGSLEYVLEEGNNKDW
FNDEHIVIGSVAMVIGAVVFFWRAFKVDFPVVDIRAFADRNFSIGSLFSFVMGIGLYGLT
YLYPLYLGRVRGYDALMIGETMFVSGLAMFFTAPIAGKVSTKLDPRVMMAIGFISFGCGT
WIMTYVTTDWDFYELLIPQILRGFGLMMCMVPINNIALGTLPPARIRNASGLFNLTRNLG
GAVGLAVINTLLSQRTDDHYVRLAEHVSYSNPQALEWLNNVGANYDSYGLDGASVAIKKL
VGMVSQQAWMLAFADVFFALTLLFGSLIFMTVLIQKPKAAPPPDAAH