Protein Info for Atu4470 in Agrobacterium fabrum C58

Annotation: iron ABC transporter ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 transmembrane" amino acids 55 to 70 (16 residues), see Phobius details PF00005: ABC_tran" amino acids 26 to 173 (148 residues), 100.4 bits, see alignment E=1.4e-32

Best Hits

Swiss-Prot: 61% identical to YFEB_YERPE: Chelated iron transport system membrane protein YfeB (yfeB) from Yersinia pestis

KEGG orthology group: K11607, manganese/iron transport system ATP-binding protein (inferred from 100% identity to atu:Atu4470)

Predicted SEED Role

"Manganese ABC transporter, ATP-binding protein SitB" in subsystem Transport of Manganese

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CV15 at UniProt or InterPro

Protein Sequence (300 amino acids)

>Atu4470 iron ABC transporter ATPase (Agrobacterium fabrum C58)
MGSKKSGGGLTVQNATVTYRNGHTALRNASFSIPRGTITALVGINGAGKSTIFKAIMGFV
PLAAGSVSIFDLPVKNALKKNLVAYVPQAEEVDWSFPVLVEDVVMMGRYGHMNFLRIPSK
RDHQMVEEALKRVNMLDYRKRQIGELSGGQKKRVFLARALAQEGQVILLDEPFTGVDVTT
EEQIVALLKALRDEGRVMLVSTHNLGSVPEFCDRAVFVKGTVLASGKTADTFNEENLQKA
FGGSLRHFVLGGAELHDDADPRRVKVITDDERPFVIYGKNGQNGHEAQPPKEKTDDKQPS