Protein Info for Atu4426 in Agrobacterium fabrum C58

Annotation: adenine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 597 PF01979: Amidohydro_1" amino acids 83 to 368 (286 residues), 91.9 bits, see alignment E=7.6e-30 PF13382: Adenine_deam_C" amino acids 419 to 584 (166 residues), 137.6 bits, see alignment E=4.5e-44

Best Hits

Swiss-Prot: 100% identical to ADEC2_AGRFC: Adenine deaminase 2 (ade2) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K01486, adenine deaminase [EC: 3.5.4.2] (inferred from 100% identity to atu:Atu4426)

Predicted SEED Role

"Adenine deaminase (EC 3.5.4.2)" in subsystem Purine conversions (EC 3.5.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.4.2

Use Curated BLAST to search for 3.5.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CUX4 at UniProt or InterPro

Protein Sequence (597 amino acids)

>Atu4426 adenine deaminase (Agrobacterium fabrum C58)
MTAQIRLAEPADLNDDTLRARAVAAARGDQRFDVLITGGTLVDVVTGELRPADIGIVGAL
IASVHEPASRRDAAQVIDAGGAYVSPGLIDTHMHIESSMITPAAYAAAVVARGVTTIVWD
PHEFGNVHGVDGVRWAAKAIENLPLRAILLAPSCVPSAPGLERGGADFDAAILADLLSWP
EIGGIAEIMNMRGVIERDPRMSGIVQAGLAAEKLVCGHARGLKNADLNAFMAAGVSSDHE
LVSGEDLMAKLRAGLTIELRGSHDHLLPEFVAALNTLGHLPQTVTLCTDDVFPDDLLQGG
GLDDVVRRLVRYGLKPEWALRAATLNAAQRLGRSDLGLIAAGRRADIVVFEDLNGFSARH
VLASGRAVAEGGRMLVDIPTCDTTVLKGSMKLPLRMANDFLVKSQGAKVRLATIDRPRFT
QWGETEADVKDGFVVPPEGATMISVTHRHGMAEPTTKTGFLTGWGRWNGAFATTVSHDSH
NLTVFGGNAGDMALAANAVIGTGGGMAVASEGKVTAILPLPLSGLVSDAPLEEVARAFED
LREAVGKVVEWQPPYLVFKACFGATLACNIGPHQTDMGIADVLTGKVMESPVIEVLG