Protein Info for Atu4206 in Agrobacterium fabrum C58

Annotation: tetracycline resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 394 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details transmembrane" amino acids 42 to 62 (21 residues), see Phobius details amino acids 73 to 93 (21 residues), see Phobius details amino acids 99 to 119 (21 residues), see Phobius details amino acids 131 to 155 (25 residues), see Phobius details amino acids 161 to 179 (19 residues), see Phobius details amino acids 210 to 234 (25 residues), see Phobius details amino acids 246 to 266 (21 residues), see Phobius details amino acids 275 to 294 (20 residues), see Phobius details amino acids 300 to 322 (23 residues), see Phobius details amino acids 336 to 357 (22 residues), see Phobius details amino acids 363 to 384 (22 residues), see Phobius details PF07690: MFS_1" amino acids 10 to 350 (341 residues), 164.7 bits, see alignment E=2.9e-52 amino acids 216 to 385 (170 residues), 49.7 bits, see alignment E=2.8e-17 PF00083: Sugar_tr" amino acids 42 to 182 (141 residues), 35.7 bits, see alignment E=4.8e-13

Best Hits

Swiss-Prot: 48% identical to TCR3_ECOLX: Tetracycline resistance protein, class C (tetA) from Escherichia coli

KEGG orthology group: K08151, MFS transporter, DHA1 family, tetracycline resistance protein (inferred from 100% identity to atu:Atu4206)

Predicted SEED Role

"Tetracycline efflux protein TetA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CUB3 at UniProt or InterPro

Protein Sequence (394 amino acids)

>Atu4206 tetracycline resistance protein (Agrobacterium fabrum C58)
MNKALIVILSTVALDAIGAGLIFPILPDILVEVTGGGDIGFLYGVMLGVFAVMQFVFSPI
LGALSDRFGRRPVLLLSLAGTLLDYLVMAFSPLGWVLVVGRAMAGITSANMAVASAYITD
ITPAEQRAQRFGTVGAVMSLGFIIGPVIGGVIGAWWLRAPFLVAALFNGLNLFVALFVLP
ESRKAGPGKFAFKELNPLAPLVWLWNFKPLLPLVTVSVVFGLVAAIPGTIWVLYGAERFG
WDSVHMGLSLSVFGVSGALAQAFLVGPLSRRFGDLGTLMIGVGFDMLAYMLMAFANQSWM
GYAVAPLFALGGVAMPALQSLVTSRVSDDQQGQLQGVLASLMSLAGIIGPVLTTAVFFST
KSIWIGTIWLVGAALYLLALPLFATVKTPKAVAA