Protein Info for Atu3581 in Agrobacterium fabrum C58

Annotation: propionyl-coenzyme A carboxylase, alpha polypeptide

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00289: Biotin_carb_N
  • amino acids 1 to 109 (109 residues), 157.7 bits, E=5.2e-50
• PF08443: RimK
  • amino acids 115 to 314 (200 residues), 26.3 bits, E=2.1e-09
• PF02786: CPSase_L_D2
  • amino acids 115 to 322 (208 residues), 275.6 bits, E=1e-85
• PF02222: ATP-grasp
  • amino acids 136 to 290 (155 residues), 33.7 bits, E=1.2e-11
• PF07478: Dala_Dala_lig_C
  • amino acids 143 to 291 (149 residues), 38.4 bits, E=3.9e-13
• PF02785: Biotin_carb_C
  • amino acids 336 to 448 (113 residues), 120.3 bits, E=1.7e-38
• PF18140: PCC_BT
  • amino acids 468 to 592 (125 residues), 102.5 bits, E=8e-33
• PF00364: Biotin_lipoyl
  • amino acids 603 to 665 (63 residues), 54.3 bits, E=3.9e-18

Best Hits

KEGG orthology group: K01965, propionyl-CoA carboxylase alpha chain [EC: 6.4.1.3] (inferred from 100% identity to atu:Atu3581)

MetaCyc: 72% identical to propionyl-CoA carboxylase alpha subunit (Cereibacter sphaeroides)
Propionyl-CoA carboxylase. [EC: 6.4.1.3]

Predicted SEED Role

"Propionyl-CoA carboxylase biotin-containing subunit (EC 6.4.1.3)" in subsystem Propionyl-CoA to Succinyl-CoA Module (EC 6.4.1.3)

MetaCyc Pathways

• propanoyl CoA degradation I (3/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (8/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (13/17 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• 3-hydroxypropanoate cycle (8/13 steps found)
• methylaspartate cycle (12/19 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
• superpathway of L-methionine salvage and degradation (8/16 steps found)
• superpathway of the 3-hydroxypropanoate cycle (8/18 steps found)
• mycolate biosynthesis (21/205 steps found)
• superpathway of mycolate biosynthesis (22/239 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.3

Use Curated BLAST to search for 6.4.1.3

Sequence Analysis Tools

See Q7CSU4 at UniProt or InterPro

Protein Sequence (667 amino acids)

>Atu3581 propionyl-coenzyme A carboxylase, alpha polypeptide (Agrobacterium fabrum C58)
MIKKILIANRGEIACRVIKTAKKMGIATVAVYSDADANALHVKMADEAVHIGPAPSSQSY
IVIDKILEAIQKTGADAVHPGYGFLSENAAFAQALEKAGVVFIGPPVGAIEAMGDKITSK
KLAAKAGVSTVPGHMGLIEDADEAVKIASQIGYPVMIKASAGGGGKGMRIAFNEAEAREG
FQSSKNEAKSSFGDDRIFIEKFVTQPRHIEIQVLGDKHGTILYLGERECSIQRRNQKVIE
EAPSPFLDEATRHAMGEQAVALARAVGYHSAGTVEFIVDGERNFYFLEMNTRLQVEHPVT
ELVTGIDLVEQMIRVASGEKLSLAQGDVKLNGWAIESRLYAEDPYRNFLPSIGRLTRYRP
PGEGAQDSGTVIRNDTGVFEGGEISMYYDPMIAKLCSWGKDRETAIDAMGEALDRFEVEG
IGHNLPFLSAVMQHERFRSGRLTTGFIAEEFPEGFSGIEPDETAARKLSAIAAIVNQRLQ
SRAVEISGTIGNHRRIVGHDWVVSFGAFRHGISVETVADGTAVRFEDGMALTIDTGWRPG
QSLGLFTVAGEVIAAKVDLAGAAVRLRWRGMDILARVRSPRVAELALLMPEKLPPDTSKL
LLCPMPGVITGISVGEGEEVEAGQALATVEAMKMENILRAEKRGRVVRVAAKPGDSLAVD
EVILEFE