Protein Info for Atu3544 in Agrobacterium fabrum C58

Annotation: arsenical pump membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 417 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 28 to 47 (20 residues), see Phobius details amino acids 52 to 72 (21 residues), see Phobius details amino acids 97 to 126 (30 residues), see Phobius details amino acids 139 to 165 (27 residues), see Phobius details amino acids 178 to 199 (22 residues), see Phobius details amino acids 218 to 239 (22 residues), see Phobius details amino acids 246 to 265 (20 residues), see Phobius details amino acids 278 to 304 (27 residues), see Phobius details amino acids 316 to 336 (21 residues), see Phobius details amino acids 357 to 384 (28 residues), see Phobius details amino acids 396 to 416 (21 residues), see Phobius details PF03600: CitMHS" amino acids 25 to 351 (327 residues), 148.7 bits, see alignment E=3.5e-47 PF02040: ArsB" amino acids 28 to 415 (388 residues), 116.5 bits, see alignment E=3.1e-37 PF00939: Na_sulph_symp" amino acids 33 to 199 (167 residues), 41.5 bits, see alignment E=1.5e-14

Best Hits

KEGG orthology group: K03893, arsenical pump membrane protein (inferred from 100% identity to atu:Atu3544)

Predicted SEED Role

"Arsenic efflux pump protein" in subsystem Arsenic resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CFD2 at UniProt or InterPro

Protein Sequence (417 amino acids)

>Atu3544 arsenical pump membrane protein (Agrobacterium fabrum C58)
MSAAYYTSAIAVATAAGVVIRPFRWPEAVWAVAGALLILALGILTPAEVWSGVIKGLDVY
LFLTGMMLLSELARREGLFDWVAAVAISYARGSSRRLFVLIYLIGVIVTALLSNDATAVV
LTPAVYAACRAARVKDPLPYLYICAFIANAASFVLPISNPANLVIFAGGEMPPLSRWLDT
FLLPSIAAIIVTFLALYWSQRRVLAEDTVADRVERPTLSLPAKLAGVGLLATAAVLLSAS
AFHMDLGLPTFLAGVITTILVLAIVRQNPVEIIKDVSWGVLPLVAGLFVIVEAVSHTGIT
AVVAEQLKALSMHSEAQAIGIGGVAVALFSNLVNNLPAGLFAASAVQAAQVPDNVTAAIL
IGVDLGPNLSVTGSLATILWLSALRREGLHVSALDFLKLGALVMTPALLASLATLLL