Protein Info for Atu3354 in Agrobacterium fabrum C58

Annotation: pyrroloquinoline-quinone-dependent quinate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 802 transmembrane" amino acids 7 to 30 (24 residues), see Phobius details amino acids 37 to 55 (19 residues), see Phobius details amino acids 61 to 77 (17 residues), see Phobius details amino acids 83 to 107 (25 residues), see Phobius details amino acids 118 to 141 (24 residues), see Phobius details TIGR03074: membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family" amino acids 11 to 801 (791 residues), 1119.7 bits, see alignment E=0 PF01011: PQQ" amino acids 223 to 254 (32 residues), 31 bits, see alignment (E = 2.2e-11) amino acids 451 to 476 (26 residues), 25.3 bits, see alignment (E = 1.4e-09) amino acids 729 to 765 (37 residues), 29 bits, see alignment 9.5e-11 PF13360: PQQ_2" amino acids 678 to 764 (87 residues), 21.5 bits, see alignment E=2.4e-08

Best Hits

Swiss-Prot: 62% identical to QUIA_ACIAD: Quinate/shikimate dehydrogenase (quinone) (quiA) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K05358, quinate dehydrogenase (quinone) [EC: 1.1.5.8] (inferred from 100% identity to atu:Atu3354)

MetaCyc: 62% identical to quinate/shikimate dehydrogenase (quinone) (Acinetobacter baylyi ADP1)
1.1.99.25-RXN [EC: 1.1.5.8]; 1.1.5.8 [EC: 1.1.5.8]

Predicted SEED Role

"Quinate/shikimate dehydrogenase [Pyrroloquinoline-quinone] (EC 1.1.99.25)" in subsystem Chorismate Synthesis or Quinate degradation (EC 1.1.99.25)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.5.8 or 1.1.99.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CF24 at UniProt or InterPro

Protein Sequence (802 amino acids)

>Atu3354 pyrroloquinoline-quinone-dependent quinate dehydrogenase (Agrobacterium fabrum C58)
MSLPARLWLLALGAVIIAAGLFFAIGGWQLVALGGSPYFIIAGLSLIVSGLLILLRKPAG
ALLFGLVFILTGVWAVWEAGLHFWPLISRLLAIGVGATVVALSYPLLRRAAGKTPAYGSS
FAVAAVLAIASGAGFAGMFVAHPTVAFNGEPAALTPVKPETEQKNWEHYGNTSGGSRFVA
LDEITRDNIKNLEVAWTYHTGDTPISPGANGAEDQQTPLQVGDTVFLCTPHNNVIALDAD
TGTEKWKAEINSKSSVWMRCRGLAYFDAKAPLKQPTAPGSTPVTAAVVAEGALCQRRILM
NTINAELIALDADTGAFCPDFGTNGRVDLKIGMGDAPDPQYVLTSAPTLAGTTVVVGGRI
ADNVQVDMPGGVMRGFDVVTGELRWAFDPGNPDITKLPPPGQTYTRSTPNVWASMSYDPD
LNTVFMPVGSPSVDLYGATRTPLDHKYGASMLALDATTGREKWVYQTVHNDLWDFDVPMQ
PSFVDFPKADGTSVPALVFGTKAGQLYVLDRATGQPLTKVEEVSVKAANIPNEPYAPTQP
RSVGMPQIGAQTLTEADMWGATPFDQLLCRIAFKGMRYEGLYTAPGTDLSLAFPGSLGGM
NWGGLSTDPTTNTIFVNDMRLGLWIEMKEAAPTKAVASGGESVNTGMGVVPMKGTPYAVN
KNRFLSALGIPCQAPPYGTMTAIDMKTQQIKWQVPVGTVEDTGPLGIKMGLPIPIGMPTL
GGTLATQGGLVFIAGTQDYYLRAFDTATGKEVWKARLPVGSQGGPMSYKSPKTGKQYVVI
SAGGARQSPDRGDYVIAYALPN