Protein Info for Atu2774 in Agrobacterium fabrum C58

Annotation: carboxy-terminal protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 442 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details PF22694: CtpB_N-like" amino acids 33 to 85 (53 residues), 35.1 bits, see alignment 3.7e-12 TIGR00225: C-terminal processing peptidase" amino acids 52 to 370 (319 residues), 341.6 bits, see alignment E=2.3e-106 PF00595: PDZ" amino acids 97 to 166 (70 residues), 40.1 bits, see alignment E=9.9e-14 PF13180: PDZ_2" amino acids 99 to 177 (79 residues), 46 bits, see alignment E=1.3e-15 PF17820: PDZ_6" amino acids 116 to 168 (53 residues), 37.8 bits, see alignment 3.3e-13 PF03572: Peptidase_S41" amino acids 197 to 364 (168 residues), 194.4 bits, see alignment E=2.7e-61

Best Hits

Swiss-Prot: 69% identical to CTPA_BARBK: Carboxy-terminal-processing protease (ctpA) from Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)

KEGG orthology group: K03797, carboxyl-terminal processing protease [EC: 3.4.21.102] (inferred from 100% identity to atu:Atu2774)

Predicted SEED Role

"Carboxyl-terminal protease (EC 3.4.21.102)" (EC 3.4.21.102)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.102

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CWA0 at UniProt or InterPro

Protein Sequence (442 amino acids)

>Atu2774 carboxy-terminal protease (Agrobacterium fabrum C58)
MIRKVSLLLIGGLMGATAMSVIYSASMPAQAAGPSTYKELSIFGDVFERVRAQYVTPPDD
EKLVENAINGMLSSLDPHSSFMNAKDANDMRTQTKGEFGGLGIEVTMENELVKVISPMDD
TPASRAGILAGDYISEIDGTPVRGLKLEQAVEKMRGAVKTPIKLTVIRKGADKPLEFTVV
RDVIAVRAVKSRVEGDNVGYLRVISFTEKTYDDLEKAIKKIKADVPADKLKGYVLDLRLN
PGGLLDQAINVSDAFLERGEVVSTRGRNPDETRRFNATAGDLTDGKPVIVLVNGGSASAS
EIVAGALQDLRRATVVGTRSFGKGSVQTIIPLGEAGALRLTTALYYTPSGKSIQGTGIEP
DIKVEQPLPAELQGRVTAEGESSLSGHIKGQSETDEGSGSSAYVPPEAKDDIQLNYALDL
LRGAKTDPSFPPNPDKAVVNKQ