Protein Info for Atu2713 in Agrobacterium fabrum C58

Annotation: ABC transporter, membrane spanning protein (thiamine)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 541 signal peptide" amino acids 1 to 42 (42 residues), see Phobius details transmembrane" amino acids 57 to 78 (22 residues), see Phobius details amino acids 90 to 113 (24 residues), see Phobius details amino acids 133 to 155 (23 residues), see Phobius details amino acids 193 to 217 (25 residues), see Phobius details amino acids 241 to 262 (22 residues), see Phobius details amino acids 288 to 313 (26 residues), see Phobius details amino acids 326 to 352 (27 residues), see Phobius details amino acids 364 to 386 (23 residues), see Phobius details amino acids 405 to 425 (21 residues), see Phobius details amino acids 464 to 488 (25 residues), see Phobius details amino acids 511 to 529 (19 residues), see Phobius details PF00528: BPD_transp_1" amino acids 71 to 260 (190 residues), 32.4 bits, see alignment E=3.8e-12

Best Hits

KEGG orthology group: K02063, thiamine transport system permease protein (inferred from 100% identity to atu:Atu2713)

Predicted SEED Role

"Thiamin ABC transporter, transmembrane component" in subsystem Thiamin biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CHG8 at UniProt or InterPro

Protein Sequence (541 amino acids)

>Atu2713 ABC transporter, membrane spanning protein (thiamine) (Agrobacterium fabrum C58)
MMLRRDYRRSIILGTAAFAAVFLFMALAVFALLSFDVGASAAGVMDAYTLRILRFTLYQA
TLSTLLSIALGLPVALALARRKEFPGRIWIIRLMAVPMGLPVIVGAFGIITIWGRQGVLN
SALVFAGADEPFSIYGLSGILIAHVFFNLPLSVRLMLAGLERIPGEYWRMAASLGMGPVS
VFRFIEWPAVSRLIPGIAGLVFMLCATSFTLVLLLGGGPAATTLEVAIYQALRFDFDPQR
AIALSVLQIVLTAVLLGLLAFLPSPEAEISSLGRNIRRFDGRTTGARLWDGAAIVFAVFL
VGLPLVAIAVSGLQADLSRLLIAPIFLRAATTSLLIAMLSAILVVLCCMAIIGARQAIGS
RRQLAWPFGLLSALLGAGSSLVLLVPPVVLGSGWFLLLRVFGDVSFYAPVLVALINMLMA
LPLAMRVMEPAFTSHFLRTGRLSASLGLQGYSRLRFADLPVLWRPMLMALSFAMALSLGD
LGAVALFGSKNFVTLPWLVYSNMGSYRTNDAAGYAFLLGVVCLLLAAGGTSRQSPSARAG
I