Protein Info for Atu2712 in Agrobacterium fabrum C58

Annotation: ABC transporter, nucleotide binding/ATPase protein (thiamine)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 238 PF00005: ABC_tran" amino acids 23 to 164 (142 residues), 118.3 bits, see alignment E=4.1e-38

Best Hits

Swiss-Prot: 100% identical to THIQ_AGRFC: Thiamine import ATP-binding protein ThiQ (thiQ) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K02062, thiamine transport system ATP-binding protein (inferred from 100% identity to atu:Atu2712)

MetaCyc: 46% identical to thiamine ABC transporter ATP binding subunit (Escherichia coli K-12 substr. MG1655)
ABC-32-RXN [EC: 7.6.2.15]

Predicted SEED Role

"Thiamin ABC transporter, ATPase component / Thiamine transport ATP-binding protein thiQ" in subsystem Thiamin biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.15

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8UBY6 at UniProt or InterPro

Protein Sequence (238 amino acids)

>Atu2712 ABC transporter, nucleotide binding/ATPase protein (thiamine) (Agrobacterium fabrum C58)
MTGDDFAVALDKIRLRLGTQNFDLDCTFPQGQVTAVVGASGSGKSTLLNLVAGFEVPDFG
RVVIHGQDMAASDPSERPVSSIFQDNNLFAHLDIFTNVALGVSPGLKLRAEDRQRIEVAL
ARVGLAGFDKRLPGTLSGGERQRAALARALVRQKPVMLLDEPFAALDPGLRAGMTALLLD
LHAETKNTVIIVTHHPDDIKKLAQRVVFLDRGRVVYAGSTADFFATQNVKAVDSFLNG