Protein Info for Atu2661 in Agrobacterium fabrum C58

Annotation: inorganic pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00719: Pyrophosphatase
  • amino acids 18 to 174 (157 residues), 202.2 bits, E=2e-64

Best Hits

Swiss-Prot: 100% identical to IPYR_AGRFC: Inorganic pyrophosphatase (ppa) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K01507, inorganic pyrophosphatase [EC: 3.6.1.1] (inferred from 100% identity to atu:Atu2661)

MetaCyc: 85% identical to inorganic diphosphatase (Sinorhizobium meliloti 1021)
Inorganic diphosphatase. [EC: 3.6.1.1]

Predicted SEED Role

"Inorganic pyrophosphatase (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

• glyphosate degradation III (7/7 steps found)
• (aminomethyl)phosphonate degradation (4/8 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.1

Use Curated BLAST to search for 3.6.1.1

Sequence Analysis Tools

See Q8UC37 at UniProt or InterPro

Protein Sequence (177 amino acids)

>Atu2661 inorganic pyrophosphatase (Agrobacterium fabrum C58)
MRIDAISIGKNPPDDINVIVEVPVGGHPIKYEMDKDAGALIVDRFLYTPMTYPGNYGFVP
HTLSDDGDPIDVLICNTRPLVPGCVINVRPIGVMIMEDDGGKDEKILAVPAPKLTQRYDK
VHNYTDLPEITLKQIEHFFEHYKDLEPGKWVKMGGWQDVDVAKKLIVEAIERYKTQG