Protein Info for Atu2502 in Agrobacterium fabrum C58

Annotation: heme oxygenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 203 PF01126: Heme_oxygenase" amino acids 19 to 195 (177 residues), 78.4 bits, see alignment E=3.4e-26

Best Hits

Swiss-Prot: 46% identical to PIGA_PSEAE: Heme oxygenase PigA (pigA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K07215, heme oxygenase (inferred from 100% identity to atu:Atu2502)

MetaCyc: 46% identical to heme oxygenase (biliverdine-IX-beta and delta-producing) (Pseudomonas aeruginosa)
RXN-18338 [EC: 1.14.99.58]; 1.14.99.58 [EC: 1.14.99.58]

Predicted SEED Role

"Heme oxygenase HemO, associated with heme uptake" in subsystem Heme, hemin uptake and utilization systems in GramPositives or Hemin transport system or Oxidative stress

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.14.99.58

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CWX1 at UniProt or InterPro

Protein Sequence (203 amino acids)

>Atu2502 heme oxygenase (Agrobacterium fabrum C58)
MTSAEPAAPVAEIEQSRVKRLKAATRGAHGDLDSFIMAAKPFESRENFGKFVETQYLFHR
DLDVFFSNVTLDGLLPDLKGRRRLAMIEQDLADLGHAIPDTDEPRFTAEMPFDLPEAMGW
LYVVEGSNLGAAFLLKDAAKLGLGEEFGARHLAGAPEGRGLHWRTFTAALDEISLTVQEE
ERVVAGAEAAFRAVHAYAQQRMG