Protein Info for Atu2458 in Agrobacterium fabrum C58

Annotation: ABC transporter, nucleotide binding/ATPase protein (hemin)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 260 PF00005: ABC_tran" amino acids 17 to 168 (152 residues), 92.9 bits, see alignment E=2.7e-30

Best Hits

Swiss-Prot: 100% identical to HMUV_AGRFC: Hemin import ATP-binding protein HmuV (hmuV) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K02013, iron complex transport system ATP-binding protein [EC: 3.6.3.34] (inferred from 100% identity to atu:Atu2458)

Predicted SEED Role

"ABC-type hemin transport system, ATPase component" in subsystem Hemin transport system

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.34

Use Curated BLAST to search for 3.6.3.34

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8UCM5 at UniProt or InterPro

Protein Sequence (260 amino acids)

>Atu2458 ABC transporter, nucleotide binding/ATPase protein (hemin) (Agrobacterium fabrum C58)
MIRAENITLIRTGRRLLDDVSVDLKPGKVNVIIGPNGAGKSTLMKVLSGEMRAEGGSVTY
NNVALPQFTPVQLARMRAVLPQNTQLAFPFTALEIVRMGAVAQGSRAPEEQARRALARAG
LRGFEQRSYNMLSGGEQQRVQFARALAQVPNSVENGEARALFLDEPTASLDIGHQISVLE
TARDFASGGGLVLAILHDLNLAAEFADQLIVMHGGRVTASGPSLDTISDETIARVYGIGG
VVGRLPARHIPYVLPQSRHR