Protein Info for Atu2418 in Agrobacterium fabrum C58

Annotation: two component sensor kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1131 transmembrane" amino acids 45 to 66 (22 residues), see Phobius details amino acids 72 to 91 (20 residues), see Phobius details amino acids 110 to 132 (23 residues), see Phobius details amino acids 144 to 164 (21 residues), see Phobius details amino acids 176 to 196 (21 residues), see Phobius details amino acids 224 to 243 (20 residues), see Phobius details amino acids 264 to 290 (27 residues), see Phobius details amino acids 320 to 342 (23 residues), see Phobius details amino acids 364 to 385 (22 residues), see Phobius details amino acids 391 to 410 (20 residues), see Phobius details amino acids 431 to 451 (21 residues), see Phobius details amino acids 461 to 480 (20 residues), see Phobius details amino acids 573 to 593 (21 residues), see Phobius details amino acids 609 to 630 (22 residues), see Phobius details PF00512: HisKA" amino acids 677 to 742 (66 residues), 58.7 bits, see alignment 7.4e-20 PF02518: HATPase_c" amino acids 789 to 898 (110 residues), 88 bits, see alignment E=9.2e-29 PF00072: Response_reg" amino acids 924 to 1033 (110 residues), 77.2 bits, see alignment E=1.6e-25

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu2418)

Predicted SEED Role

"Two-component hybrid sensor and regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CHV9 at UniProt or InterPro

Protein Sequence (1131 amino acids)

>Atu2418 two component sensor kinase (Agrobacterium fabrum C58)
MAARQRIIPVRREYNRWVANQTLEDYALRFTAKSARQFSSNRISHTAIGAISFLALEAIG
GAITLSYGTTNAFYAIIVAAIAMLAVGLPISRYAIRHGVDIDLLTRGASFGYIGSTITSL
IYAAFTFMLFAIEASIMSGALELALGIPLWIGYIISAVMVIPLVTHGVRLISRFQIITQP
FWIVLNILPFIFIALMDWEKYDLWRAFSGIHHASGPPGTVADFNLVEFGAASAVILALMS
QIGEQVDFLRFLPAEGQSRVRHRIAVFLAGAGWVVVGVPKLLAGSFLVVLTFSSGVSVDR
AADPAQMYLTAFGYMVPNETAAMLLMVAFVVVSQLKINVMNAYAGSLAWSNFFSRLTHSH
PGRVVWLVFNVAIALLLMELGIYRLLEETLGIFSIIAMAWLCTISADLFINKPLGLAPPG
IEFKRAHLYDINPVGVGSMALSATIALMAHFGTFGPLAASLAPYLTLIVAFIASPALALA
TKGKFYLARKPRQKWHEESSITCSICEHPFEPEDMAWCPAYAAPICSLCCSLDSRCHDMC
KPKAKLNYQVASVAKTFLPRQLVAKLATRLGRYGMAAAIAVTAIGGILALIAHQVGTASP
ATADVVNRTILIVFFVFAVIAGIVCWFLVLAHDSRVVAEEESSRQNTLLLKEIAAHKKTD
AALQDAKETAEAANRAKSRYVVGLSHELRTPLNAVLGYAQILERDETIPAPRQSAIKVIR
RSADHLSGLIDGLLDISKIEAGRLQVYSNEINIKDFLDQVVDMFRPQAQAKGLEFRHERT
AALPQYVRTDEKRLRQILVNLLSNAIKFTDEGSVTFDVAYRSQVASFTVSDTGRGIAEKD
LARIYEPFQRGEAESVRPMPGLGLGLTITRLLTNTLGGEISVSSEKDNGSTFRVRLMLSA
VHRPSTAPAPEKTIRSYSGPRRTIVVVDDNEDHRELMRQVLSPLDFVVLTAQSGPECLTL
IEGVKPDLFLIDISMPGMTGWQLVTKLREAGQTAPLIMLSANIGDGAVAGAGDDNHNDAI
AKPVDIRHLCDRLAVHLGLKWIYETDLPSAPVTQPPAQVVHPGAIHIKDLQRLGEIGYIR
GIEAKLADLARNTDNLPFTQELGTYVQAFDLAGYAHFLKRFEDNDRGDGGA