Protein Info for Atu2287 in Agrobacterium fabrum C58

Annotation: outer membrane heme receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 746 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details TIGR01785: TonB-dependent heme/hemoglobin receptor family protein" amino acids 40 to 746 (707 residues), 380.7 bits, see alignment E=1.5e-117 TIGR01786: TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein" amino acids 42 to 746 (705 residues), 415.3 bits, see alignment E=5.1e-128 PF07715: Plug" amino acids 58 to 171 (114 residues), 58.5 bits, see alignment E=1.3e-19 PF00593: TonB_dep_Rec_b-barrel" amino acids 277 to 702 (426 residues), 196.7 bits, see alignment E=2e-61 PF14905: OMP_b-brl_3" amino acids 393 to 626 (234 residues), 37.3 bits, see alignment E=2.8e-13

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 100% identity to atu:Atu2287)

Predicted SEED Role

"TonB-dependent hemin , ferrichrome receptor" in subsystem Hemin transport system or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CI28 at UniProt or InterPro

Protein Sequence (746 amino acids)

>Atu2287 outer membrane heme receptor (Agrobacterium fabrum C58)
MSISRTHSALLLCTAISLLPLAGPARAQDAASQENGTTTLEKIVVKGKRVKSANAAADTP
LASQTTAEDIRKKDIGSIKDLGNTTEPGVDYVDSKPGRPGGLFIRGLGGARVVTLIDNIP
VPYFNNFARQGQATTTLSDTSSSFDFSSLSSVDVVRGADSSRIGSGALGGALVLRTLEPE
DLIGEGKDWGGVAKTSYDSEDRSVGGSLAVAKKIENTSVLFQGSYKRGNETDNRGTADIY
GTRRTKPNPADTYESNLMFKIRQDLEGGHRIGLTAERYSLRNRSDMKTLQGVSVSGSTYR
IGDYRGYEDTERDRVSLDYEYEAPSTDGVIDAANLSLYWTRLSKESGAGDRLTNNSLYIR
EDSMRNSAFGIVGGLESGFELGGVQHTVRFGGNAMTTDFSQELFANTAGVTSSSQSDMPD
VSGKSLGLYLDDEIAFGNGFRLTPGLRFDSYDYDPDGSVSSNSGYRTFGLPSGNSGSRFS
PKLLATYDVTPELQLFAQWSMAYRAPTINELYLNFSNISSGYAVVGNSALNPETSNGFEI
GANYASGDLTGSLTLFHNKYKDFIEQYTTSTTLFPGFGGRGNGSLFTYRNRNNVEISGVE
AKVRKELANGFFAHASLAYAYGKDTDTNEFIRTVAPFKSILGVGYAQEVWGTELTGVFSS
GMRDDGVASTFDAPGYGVFNLTGWWEPEQTKGLRIQAGVYNLFDRKYWNGVGVRDVNPNS
VSTVNQPVDFYTEAGRTFKISLTQKF