Protein Info for Atu2282 in Agrobacterium fabrum C58

Annotation: thymidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to KITH_AGRFC: Thymidine kinase (tdk) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K00857, thymidine kinase [EC: 2.7.1.21] (inferred from 100% identity to atu:Atu2282)

Predicted SEED Role

"Thymidine kinase (EC 2.7.1.21)" in subsystem Folate Biosynthesis (EC 2.7.1.21)

MetaCyc Pathways

superpathway of pyrimidine deoxyribonucleoside salvage (8/9 steps found)
pyrimidine deoxyribonucleosides salvage (4/5 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CXF9 at UniProt or InterPro

Protein Sequence (163 amino acids)

>Atu2282 thymidine kinase (Agrobacterium fabrum C58)
MRTLIFTAAFDDRAGVGRVASRIGLSSEARTFDENTDLFAEVAALHAQAPVACVFVDEAN
FLSEHHVWQLANIADRLNIPVMTYGLRTDFQGKLFPASKELLAIADELREIRTICHCGRK
ATMVARFDSEGKVVTEGAQIEVGGNGKYVSFCRRHWVETFNCS