Protein Info for Atu2228 in Agrobacterium fabrum C58

Annotation: GGDEF family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 795 transmembrane" amino acids 9 to 33 (25 residues), see Phobius details amino acids 145 to 167 (23 residues), see Phobius details PF00672: HAMP" amino acids 170 to 216 (47 residues), 28.9 bits, see alignment 2.4e-10 TIGR00229: PAS domain S-box protein" amino acids 230 to 349 (120 residues), 46.3 bits, see alignment E=4.5e-16 PF00989: PAS" amino acids 231 to 335 (105 residues), 26.9 bits, see alignment E=8.2e-10 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 352 to 515 (164 residues), 139.1 bits, see alignment E=1.2e-44 PF00990: GGDEF" amino acids 354 to 510 (157 residues), 144.9 bits, see alignment E=3.9e-46 PF00563: EAL" amino acids 531 to 771 (241 residues), 229.3 bits, see alignment E=9e-72

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu2228)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CI55 at UniProt or InterPro

Protein Sequence (795 amino acids)

>Atu2228 GGDEF family protein (Agrobacterium fabrum C58)
MAHSVESRFIAIVSGALLTVVAPLFTLLLTLSYNEAIRSQRNHIEILLSTNTQALARPLW
DLDDDTINQITGTLVSDPMIRMVEVKDTSGQLDVVQTAGSDIIQDAASTTREVIYKTTKG
PVTVGQLTVYYDDVGLLTSLSRTELAFITIFILAVLTIVLAAIVGNRFMVIRPLMRLAAA
IEATRRLGSRHHVDWRSKDEIGRLAKSFNEMQTQLEKEELEIKNAHERKTEIYNRTPAML
FSLDRHDRIAAVSDYWVQATGYDRTRILGLNFADLIHPDDRSLFQQRKTAHPSPDASHNG
ITVRFHCMDGGVMDALILEKPLDSGDTTQQSTCLCVMTDVTELSQSEKRNRQQAISDHLT
GLFNRQGFEAILDLQIRDADRNGSELACLFIDLDRFKAINDNLGHAAGDAVLKQFTLKLE
PLLTPLDSASRLGGDEFAILLAGDKVEERALEFCERVCAMLDMPFEIENNSIRLSASIGM
AVYPLHASSASELLQNADMAMYSRKRTGKNGSQVFDSSIMDRAREHAELERDIAQALSED
WFEAYFQPIQDLATGQTAGFEALLRLNHPDKGLLSPAAIVSLAEENGTIQRIGNLILDQS
IANLARLSRLPGMDQTYVAVNFSPLQFEPGLPTRIAGVLHRHGILPARLVIEITEAVIMK
DDPQIRAILNAIHQLGCRIALDDFGTGYSSLSYLSRFPVDIVKIDQSFTRSICDDTVDIR
QRSRMLVEGIAAISHKMNCTVIAEGVETEEQKDLLTDMGADFGQGYYFARPQPVQRLIAA
FDATSGQSRFAARQA