Protein Info for Atu2218 in Agrobacterium fabrum C58

Annotation: ribose-phosphate pyrophosphokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 310 PF13793: Pribosyltran_N" amino acids 1 to 117 (117 residues), 185 bits, see alignment E=5.2e-59 TIGR01251: ribose-phosphate diphosphokinase" amino acids 1 to 310 (310 residues), 391.8 bits, see alignment E=9e-122 PF00156: Pribosyltran" amino acids 148 to 249 (102 residues), 82.7 bits, see alignment E=2.8e-27 PF14572: Pribosyl_synth" amino acids 198 to 309 (112 residues), 80.1 bits, see alignment E=3.2e-26

Best Hits

Swiss-Prot: 100% identical to KPRS_AGRFC: Ribose-phosphate pyrophosphokinase (prs) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K00948, ribose-phosphate pyrophosphokinase [EC: 2.7.6.1] (inferred from 99% identity to agr:AGROH133_07724)

MetaCyc: 54% identical to ribose-phosphate diphosphokinase (Escherichia coli K-12 substr. MG1655)
Ribose-phosphate diphosphokinase. [EC: 2.7.6.1]

Predicted SEED Role

"Ribose-phosphate pyrophosphokinase (EC 2.7.6.1)" in subsystem De Novo Purine Biosynthesis or Pentose phosphate pathway (EC 2.7.6.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.6.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8UDA9 at UniProt or InterPro

Protein Sequence (310 amino acids)

>Atu2218 ribose-phosphate pyrophosphokinase (Agrobacterium fabrum C58)
MKVFAGNSNRHLAEAICKYLNVPLGNATVKRFADQEIFVEISENVRGEDVFIVQSTSFPA
NDHLMELLIMIDAMRRSSAKRITAVLPYFGYARQDRKAGPRTPISAKLVANLITEAGADR
VLTLDLHAGQIQGFFDIPTDNLFAAPILARDVKDHYDTNNVMVVSPDVGGVVRARALSKR
LDCLLAIVDKRRDRPGESEVMNVIGDVSGKDCILIDDIIDSGGTLCNAAEALLKKGATSV
TAYITHGVLSGGAVARVASSKLRELVITDSIQPTTGVQSAHNIRVVSTAGLLGEAINRTA
QEQSVSGLFD