Protein Info for Atu2057 in Agrobacterium fabrum C58

Annotation: DNA helicase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 824 PF00580: UvrD-helicase" amino acids 56 to 325 (270 residues), 297 bits, see alignment E=5e-92 PF13604: AAA_30" amino acids 56 to 122 (67 residues), 27.1 bits, see alignment E=1e-09 PF13245: AAA_19" amino acids 60 to 308 (249 residues), 78.5 bits, see alignment E=1.7e-25 PF13361: UvrD_C" amino acids 330 to 659 (330 residues), 219.2 bits, see alignment E=3.2e-68

Best Hits

KEGG orthology group: K03657, DNA helicase II / ATP-dependent DNA helicase PcrA [EC: 3.6.4.12] (inferred from 100% identity to atu:Atu2057)

Predicted SEED Role

"ATP-dependent DNA helicase UvrD/PcrA" in subsystem DNA repair, bacterial UvrD and related helicases

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.12

Use Curated BLAST to search for 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CXZ3 at UniProt or InterPro

Protein Sequence (824 amino acids)

>Atu2057 DNA helicase II (Agrobacterium fabrum C58)
MSNSFDDMPFFDEEPVAPRRATNNAPSENGGGLGIAARAMAARDQVRPAHDYLSGLNPEQ
REAVETLDGPVLVLAGAGTGKTRVLTTRIAHILATGRAYPSQILAVTFTNKAAREMKERI
GVLVGGAVEGMPWLGTFHSIGVKLLRRHAELIGLKSDFTILDTDDVVRLIKQLIQAEGLD
DKRWPAKQFAGMIDGWKNKGLTPPDIPEGDSRAFANGKGRELYAAYQARLKTLNACDFGD
LLLHPISIFRRHTDILKEYHQKFRYILVDEYQDTNTAQYMWLRLLAQRAKDEPQNVCCVG
DDDQSIYGWRGAEVDNILRFDKDFPGAKVIKLERNYRSTEHILGAAGHLIAHNEGRLGKT
LFTERSSPDDEKVVVHAAWDSEEEARAVGEEIEQLQRKNYKLNDMAILVRASFQMREFED
RFVTLGLNYRVIGGPRFYERLEIRDAMAYFRLVCQPADDLAFERIVNTPKRGLGDTTIRN
LHDYARARDIPMLAAAADIIETDELKPKARKALFDVVQDFRRWQGLLENTEHTTLAEQIL
DESGYTAMWQADKTAEAPGRLENLKELIRSMESFESMRGFLEHVALVMDAEQNAELDAVS
IMTLHSAKGLEFDTVFLPGWEEGLFPHQRALDEGGRSGLEEERRLAYVGITRAKKLCHIW
FVSNRRIHGLWQSTLPSRFLDELPPAHVDVAASDSNYGGYGGRGGYGQSRFDKADPFTNN
YSTPGWKRAQQNRSDATRDNWGTRSGHAVERIGYGESGPRTRTIDGELVAKSVADKPSKF
FVGDRVFHLKFGNGNISAIEGNKLTINFDRAGEKRVLDGFVEKV