Protein Info for Atu2022 in Agrobacterium fabrum C58
Annotation: NADP-dependent alcohol dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 65% identical to ADHC2_MYCS2: NADP-dependent alcohol dehydrogenase C 2 (adhC2) from Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
KEGG orthology group: K00002, alcohol dehydrogenase (NADP+) [EC: 1.1.1.2] (inferred from 100% identity to atu:Atu2022)MetaCyc: 49% identical to sinapyl alcohol dehydrogenase (Populus tremuloides)
Cinnamyl-alcohol dehydrogenase. [EC: 1.1.1.195]
Predicted SEED Role
"Alcohol dehydrogenase (EC 1.1.1.1)" in subsystem Fermentations: Mixed acid or Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 1.1.1.1)
MetaCyc Pathways
- 3-methylbutanol biosynthesis (engineered) (6/7 steps found)
- ethanol degradation II (3/3 steps found)
- pyruvate fermentation to isobutanol (engineered) (4/5 steps found)
- acetaldehyde biosynthesis I (1/1 steps found)
- phytol degradation (3/4 steps found)
- L-isoleucine degradation II (2/3 steps found)
- L-leucine degradation III (2/3 steps found)
- L-valine degradation II (2/3 steps found)
- erythritol biosynthesis I (1/2 steps found)
- erythritol biosynthesis II (1/2 steps found)
- ethanol degradation I (1/2 steps found)
- pyruvate fermentation to ethanol II (1/2 steps found)
- glycerol degradation to butanol (11/16 steps found)
- superpathway of anaerobic sucrose degradation (13/19 steps found)
- D-xylose degradation to ethylene glycol (engineered) (2/4 steps found)
- L-phenylalanine degradation III (2/4 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (2/4 steps found)
- L-tyrosine degradation III (2/4 steps found)
- heterolactic fermentation (12/18 steps found)
- L-methionine degradation III (1/3 steps found)
- pyruvate fermentation to ethanol I (1/3 steps found)
- pyruvate fermentation to ethanol III (1/3 steps found)
- pyruvate fermentation to butanol I (4/8 steps found)
- capsiconiate biosynthesis (1/4 steps found)
- cytidine-5'-diphosphate-glycerol biosynthesis (1/4 steps found)
- salidroside biosynthesis (1/4 steps found)
- serotonin degradation (3/7 steps found)
- mixed acid fermentation (9/16 steps found)
- (S)-propane-1,2-diol degradation (1/5 steps found)
- acetylene degradation (anaerobic) (1/5 steps found)
- ethanolamine utilization (1/5 steps found)
- phenylethanol biosynthesis (1/5 steps found)
- butanol and isobutanol biosynthesis (engineered) (3/8 steps found)
- superpathway of fermentation (Chlamydomonas reinhardtii) (3/9 steps found)
- hexitol fermentation to lactate, formate, ethanol and acetate (10/19 steps found)
- superpathway of N-acetylneuraminate degradation (12/22 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (5/13 steps found)
- detoxification of reactive carbonyls in chloroplasts (2/10 steps found)
- noradrenaline and adrenaline degradation (4/13 steps found)
- traumatin and (Z)-3-hexen-1-yl acetate biosynthesis (3/12 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (5/17 steps found)
- monolignol biosynthesis (3/15 steps found)
- L-tryptophan degradation V (side chain pathway) (1/13 steps found)
- superpathway of lipoxygenase (4/22 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- Biosynthesis of phenylpropanoids
- Caprolactam degradation
- Drug metabolism - cytochrome P450
- Fatty acid metabolism
- Glycerolipid metabolism
- Glycine, serine and threonine metabolism
- Glycolysis / Gluconeogenesis
- Metabolism of xenobiotics by cytochrome P450
- Phenylpropanoid biosynthesis
- Retinol metabolism
- Tyrosine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.1, 1.1.1.195
Use Curated BLAST to search for 1.1.1.1 or 1.1.1.195 or 1.1.1.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See Q7CY20 at UniProt or InterPro
Protein Sequence (348 amino acids)
>Atu2022 NADP-dependent alcohol dehydrogenase (Agrobacterium fabrum C58) MAIARGYAATDASKPLTPFTFERREPNDDDVVIDIKYAGICHSDIHTVRNEWHNAVYPIV PGHEIAGVVRAVGSKVTRFKVGDHVGVGCFVDSCVGCATRDVDNEQYMPGLVQTYNSVER DGKSATQGGYSDHIVVREDYVLSIPDNLPLDASAPLLCAGITLYSPLQHWNAGPGKKVAI VGMGGLGHMGVKIGSAMGADITVLSQTLSKKEDGLKLGAKEYYATSDASTFEKLAGTFDL ILCTVSAEIDWNAYLNLLKVNGTMVLLGVPEHAIPVHAFSVIPARRSLAGSMIGSIKETQ EMLDFCGKHDIVSEIETIGIKDVNEAYERVLKSDVRYRFVIDMASLDA