Protein Info for Atu1736 in Agrobacterium fabrum C58

Annotation: manganese transport protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 456 transmembrane" amino acids 48 to 66 (19 residues), see Phobius details amino acids 84 to 108 (25 residues), see Phobius details amino acids 128 to 151 (24 residues), see Phobius details amino acids 156 to 178 (23 residues), see Phobius details amino acids 185 to 207 (23 residues), see Phobius details amino acids 231 to 250 (20 residues), see Phobius details amino acids 274 to 298 (25 residues), see Phobius details amino acids 320 to 348 (29 residues), see Phobius details amino acids 369 to 387 (19 residues), see Phobius details amino acids 393 to 417 (25 residues), see Phobius details amino acids 429 to 450 (22 residues), see Phobius details TIGR01197: metal ion transporter, metal ion (Mn2+/Fe2+) transporter (Nramp) family" amino acids 49 to 423 (375 residues), 393.5 bits, see alignment E=6.5e-122 PF01566: Nramp" amino acids 71 to 427 (357 residues), 447.9 bits, see alignment E=1.3e-138

Best Hits

Swiss-Prot: 100% identical to MNTH_AGRFC: Divalent metal cation transporter MntH (mntH) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K03322, manganese transport protein (inferred from 100% identity to atu:Atu1736)

Predicted SEED Role

"Manganese transport protein MntH" in subsystem Transport of Manganese

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q8UEM1 at UniProt or InterPro

Protein Sequence (456 amino acids)

>Atu1736 manganese transport protein (Agrobacterium fabrum C58)
MICNCINSISMKAQKMDKPVFGWRRNGDDLSLSDVHSSIRIKPDASTFRRAMAFFGPGYL
VAVGYMDPGNWATSLAGGSKFGYTLLAVALVSNIMAIVLQSLCARLAIASGRDLAQACRD
AYPKPVAMVLWLLAEIAIIATDIAEVIGTAIGLNLIFGIPLELGVLITALDVFLILYLQK
LGFRWVEALVITLLGVIAVCFAIQLALADPDWGQVILGFAPTTEIVTNPDMLYLALGILG
ATVMPHNLYLHSGIVQTREIGPTIAEKREALKFATLDSTIALMFALLINASILILAAATF
NKTGQTNVAELGEAHSLLAPLLGLAIAPTLFGVALLCCGINSTVTATLAGQIVMEGFLKM
RLAPWLRRLITRAIAIVPAAGVTIFYGDSGTGQLLILTQVVLSLQLSFAVFPLVMFTSDK
AKMGELRSPLWLSAIAWLIAVVIAALNVKLLMDFMG