Protein Info for Atu1626 in Agrobacterium fabrum C58

Annotation: NAD dependent epimerase/dehydratase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF04321: RmlD_sub_bind
  • amino acids 1 to 157 (157 residues), 65.1 bits, E=2.1e-21
• PF01370: Epimerase
  • amino acids 3 to 161 (159 residues), 85.5 bits, E=1.3e-27
• PF13460: NAD_binding_10
  • amino acids 7 to 193 (187 residues), 40.1 bits, E=1.3e-13
• PF02719: Polysacc_synt_2
  • amino acids 34 to 106 (73 residues), 29.5 bits, E=1.6e-10
• PF01073: 3Beta_HSD
  • amino acids 38 to 147 (110 residues), 50.2 bits, E=6.7e-17
• PF16363: GDP_Man_Dehyd
  • amino acids 39 to 147 (109 residues), 41 bits, E=6e-14
• PF07993: NAD_binding_4
  • amino acids 47 to 162 (116 residues), 30.2 bits, E=8.8e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to atu:Atu1626)

Predicted SEED Role

"UDP-glucose 4-epimerase (EC 5.1.3.2)" in subsystem Lacto-N-Biose I and Galacto-N-Biose Metabolic Pathway or Lactose and Galactose Uptake and Utilization or N-linked Glycosylation in Bacteria or Rhamnose containing glycans or linker unit-arabinogalactan synthesis (EC 5.1.3.2)

MetaCyc Pathways

• colanic acid building blocks biosynthesis (11/11 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (5/6 steps found)
• UDP-α-D-galactofuranose biosynthesis (2/2 steps found)
• UDP-α-D-galactose biosynthesis (1/1 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis I (1/1 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis II (5/7 steps found)
• D-galactose degradation I (Leloir pathway) (3/5 steps found)
• stachyose degradation (4/7 steps found)
• D-galactose detoxification (1/3 steps found)
• UDP-sugars interconversion (4/9 steps found)
• teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (13/33 steps found)
• mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (2/18 steps found)

KEGG Metabolic Maps

• Galactose metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 5.1.3.2

Use Curated BLAST to search for 5.1.3.2

Sequence Analysis Tools

See A9CIU6 at UniProt or InterPro

Protein Sequence (296 amino acids)

>Atu1626 NAD dependent epimerase/dehydratase family protein (Agrobacterium fabrum C58)
MRIVLTGSSGRVGRAIFSALAGRHDVTGIDRSPFSTTHIVDDFADESLLRRAFERADAVI
HTAALHAPHVGCVPNAEFQRINVDGARMVAEAAMATGVPRLVFTSTTALYGHAVSSGSCT
FIDEDTPPQPKSIYHRTKLEAEHLLEEMAGPHLAVRVLRMSRSFPEPADVMAAYRQHRGV
DIRDVADAHVLALGNAGEDFQRYIVSASTPFFADDCDALAKDAPSVLRQRTPGLTDAFAQ
EGWALPTTIDRVYSPARAVEGLGWTSQFGSDEVLAQLARRSLEVLPAGANIGRKSE