Protein Info for Atu1575 in Agrobacterium fabrum C58

Annotation: cystathionine beta lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 395 PF01053: Cys_Met_Meta_PP" amino acids 15 to 389 (375 residues), 347.1 bits, see alignment E=4.7e-108 TIGR01324: cystathionine beta-lyase" amino acids 15 to 391 (377 residues), 557.8 bits, see alignment E=4.7e-172

Best Hits

Swiss-Prot: 70% identical to METC_RHIL3: Putative cystathionine beta-lyase (metC) from Rhizobium leguminosarum bv. viciae (strain 3841)

KEGG orthology group: K01760, cystathionine beta-lyase [EC: 4.4.1.8] (inferred from 100% identity to atu:Atu1575)

Predicted SEED Role

"Cystathionine beta-lyase (EC 4.4.1.8)" in subsystem Methionine Biosynthesis (EC 4.4.1.8)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.4.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CIW9 at UniProt or InterPro

Protein Sequence (395 amino acids)

>Atu1575 cystathionine beta lyase (Agrobacterium fabrum C58)
MTKTNDLRSAAGVNTRLTHGGNDPADCFGFVNPPIVRGSTVLFPDAETLSTEDQKYTYGT
HGTPTTDALCNLVNELEGSFGTILVPSGLAAITVPFLAYLGAGDHALIVDSVYFPTRRFC
NTMLKKLGVEVEYYDPAIGAGIEALIRPNTKLVHLEAPGSNTFEIQDVRLITDIAHRHDC
VVTMDNTWATPLYFKPLDFGVDVSIHAATKYPSGHSDVLMGFVSANEKYWKALYQANTNL
GICVTPDDAYQILRGMRTMGIRLEHHQKSALDIAQWLEGRDDVVRVLHPALPSFAGHELW
KRDFKGASGVFSFVLKAEEGKYKQTASAFLDALTFFGLGYSWGGYESLAVSVSLVDRTIA
KGPSEGPVIRLQIGLEDVADLKKDLEAGFSAAAGV