Protein Info for Atu1362 in Agrobacterium fabrum C58

Annotation: two component sensor kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 861 transmembrane" amino acids 23 to 44 (22 residues), see Phobius details amino acids 52 to 76 (25 residues), see Phobius details PF00989: PAS" amino acids 89 to 196 (108 residues), 23.2 bits, see alignment E=1.7e-08 TIGR00229: PAS domain S-box protein" amino acids 89 to 210 (122 residues), 23.8 bits, see alignment E=2.1e-09 PF13426: PAS_9" amino acids 96 to 202 (107 residues), 18.3 bits, see alignment E=6.8e-07 amino acids 351 to 445 (95 residues), 10.8 bits, see alignment E=0.00015 PF13188: PAS_8" amino acids 341 to 379 (39 residues), 19.9 bits, see alignment (E = 1.6e-07) PF08448: PAS_4" amino acids 346 to 459 (114 residues), 24.5 bits, see alignment E=8.1e-09 PF02518: HATPase_c" amino acids 582 to 702 (121 residues), 85.1 bits, see alignment E=1.5e-27 PF00072: Response_reg" amino acids 742 to 853 (112 residues), 78.6 bits, see alignment E=1.2e-25

Best Hits

KEGG orthology group: K13587, two-component system, cell cycle sensor histidine kinase and response regulator CckA [EC: 2.7.13.3] (inferred from 100% identity to atu:Atu1362)

Predicted SEED Role

"sensory box histidine kinase/response regulator"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7CZE9 at UniProt or InterPro

Protein Sequence (861 amino acids)

>Atu1362 two component sensor kinase (Agrobacterium fabrum C58)
MTRVRETSDNDLPLVDRRARSGTVLRILLLALVLIAAAAAFVYFKDSLENEIVLGILGVL
AMMGIFFLVSSIIGFIEVMPQSQSDGLARRFLSAHPEGTLITDAKGHMVYANATYCRMSG
TTKASDIQSLETLLSRSRESTEALYRLINVLREGRDGYEEFRLLKPLGDDTGAGPHWYRL
KGRVLKDAGGEGLHVFQIADITPEREDQERFFRELQNAIDYLDHAPAGFFSASRKGEIVY
LNATLSEWLGIDLAQFSPGSMTISDIVAGEGMALIDSVHPQGTAKRTEILDLDMRRVNGQ
SMPARLVHQVTAKDGAPGESRTIVLMRSKGQEDTESSSAMRFTRFFNNTPMAIASLDGEG
RILRINAPFLKLFSGVVGRDDIDRGVALETVLHDNEKPRLEQALAEAKDRQGDIAPFDSR
HPSDEGRHFRFYVNAVIDQDDEAPEEVAIVYAIEVTEQKALETQMAQTQKMNAVGTLAGG
IAHDFNNVLTAILLSSDHLLLQARPADPSFADLMEIKRNANRAAVLVRQLLAFSRKQTMR
PAVLNLTDVIGDLRMLVDRLISGTNVKLEVDYGRDLWPVKTDLSQFEQVLINLCVNARDA
MPDGGKITIRTRNVDEKEIAALGRPEFPAEDMVMVEVADNGTGIPPEIMDKIFEPFFTTK
EVGKGTGLGLSMVYGIVKQSGGYIYPESEVGKGTAFRIYLPRHVVEVVQVMGQDGEMVAA
PVVAAEPVKEEPLDLTGKSAVVLLVEDEEAVRRGGKRMLETRGYTVHEAGSGIEALEVME
ELEGKVDIVVSDVVMPEMDGPSLLRELRKSYPDLKFIFVSGYAEDAFARNLPADAKFGFL
PKPFSLKQLAIAVREMLDDKE