Protein Info for Atu0794 in Agrobacterium fabrum C58

Annotation: cell cycle regulated site-specific DNA-methyltransferase protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 381 PF01555: N6_N4_Mtase" amino acids 45 to 266 (222 residues), 238.2 bits, see alignment E=1.1e-74 PF18755: RAMA" amino acids 280 to 377 (98 residues), 61.8 bits, see alignment E=5.3e-21

Best Hits

Swiss-Prot: 85% identical to MTS1_RHIME: Modification methylase SmeI (smeIM) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K13581, modification methylase [EC: 2.1.1.72] (inferred from 100% identity to atu:Atu0794)

Predicted SEED Role

"Modification methylase"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.72

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A9CJW0 at UniProt or InterPro

Protein Sequence (381 amino acids)

>Atu0794 cell cycle regulated site-specific DNA-methyltransferase protein (Agrobacterium fabrum C58)
MAAVFPLADFRRAGFDRAGESDAWKDSIIKGDCVAALDALPSQSVDAIFADPPYNLQLGG
TLHRPDQSLVDAVDDEWDQFASFDAYDAFTRAWLLACRRVLKPNGTIWVIGSYHNIFRVG
AMLQNLDFWILNDIVWRKTNPMPNFKGRRFQNAHETMIWASRDPKAKSYTFNYDALKASN
DDVQMRSDWLFPICSGHERLKGDDGKKVHPTQKPEALLARIIMASTKPGDIVLDPFFGSG
TTGAVAKRLGRHFVGIEREQDYIDAASARITAVEPLGKAELTVMTGKKAEPRVAFNTLVE
SGLVRPGQVLTDARRRYSAIIRADGTLASGGTAGSIHRLGAKVQGLDACNGWTFWHFEDG
DALKPIDDLRTIIRSEMAKAE