Protein Info for Atu0599 in Agrobacterium fabrum C58

Annotation: 6-phosphogluconolactonase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01198: 6-phosphogluconolactonase
  • amino acids 7 to 224 (218 residues), 181.9 bits, E=7.3e-58
• PF01182: Glucosamine_iso
  • amino acids 10 to 222 (213 residues), 187.1 bits, E=2.2e-59

Best Hits

Swiss-Prot: 64% identical to 6PGL_RHIME: 6-phosphogluconolactonase (pgl) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01057, 6-phosphogluconolactonase [EC: 3.1.1.31] (inferred from 100% identity to atu:Atu0599)

Predicted SEED Role

"6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type" in subsystem Entner-Doudoroff Pathway or Pentose phosphate pathway (EC 3.1.1.31)

MetaCyc Pathways

• superpathway of glucose and xylose degradation (16/17 steps found)
• pentose phosphate pathway (8/8 steps found)
• Entner-Doudoroff pathway I (8/9 steps found)
• pentose phosphate pathway (oxidative branch) I (3/3 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (13/17 steps found)
• heterolactic fermentation (12/18 steps found)
• formaldehyde oxidation I (3/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.1.31

Sequence Analysis Tools

See Q7D149 at UniProt or InterPro

Protein Sequence (232 amino acids)

>Atu0599 6-phosphogluconolactonase (Agrobacterium fabrum C58)
MSETIHVFDTAAALATALAAEVAKRLDAATKERGTASIAVSGGSTPKLFFQALSRHDLDW
PNISVTLVDERFVPPESDRSNHRLVADNLLQDKAKAAYFVPLFQPAASPEDAATLATVKT
EAICDPFDVVILGMGTDGHTASFFPGGDNLYEALDLDEPRGVLTMAAENAGEERLTFNFS
SLHDADFLVLHIEGAAKKATLEKAQSGEDEDEMPVRAVLNRAETPVDIYWAP