Protein Info for Atu0316 in Agrobacterium fabrum C58

Annotation: DNA/pantothenate metabolism flavoprotein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 401 transmembrane" amino acids 6 to 19 (14 residues), see Phobius details TIGR00521: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase" amino acids 4 to 394 (391 residues), 405.4 bits, see alignment E=1.3e-125 PF02441: Flavoprotein" amino acids 6 to 180 (175 residues), 120.7 bits, see alignment E=4.7e-39 PF04127: DFP" amino acids 188 to 372 (185 residues), 235.4 bits, see alignment E=4.4e-74

Best Hits

Swiss-Prot: 48% identical to COABC_ALIF1: Coenzyme A biosynthesis bifunctional protein CoaBC (coaBC) from Aliivibrio fischeri (strain ATCC 700601 / ES114)

KEGG orthology group: K13038, phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase [EC: 4.1.1.36 6.3.2.5] (inferred from 100% identity to atu:Atu0316)

Predicted SEED Role

"Phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) / Phosphopantothenoylcysteine synthetase (EC 6.3.2.5)" in subsystem Coenzyme A Biosynthesis (EC 4.1.1.36, EC 6.3.2.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.36 or 6.3.2.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q7D1P8 at UniProt or InterPro

Protein Sequence (401 amino acids)

>Atu0316 DNA/pantothenate metabolism flavoprotein (Agrobacterium fabrum C58)
MTLSGKHILLIISGGIAAYKSLDLIRRLKERGAKVTPVMTKGAQEFVTPLAVGALSASNV
FTEIFSRQDEQDVGHIRLARDCDLVLVAPATADLMAKMANGLADDLASAVLLATDRKVLV
APAMNPKMWSAKPTMRNVETLKRDGVFFIGPMAGEMAETGEAGLGRMAEPLQIVEAVLSL
LDGSSKPLKGKTAIVTSGPTHEPIDPVRYIANRSSGKQGHAIAAALAALGAEVTLVSGPV
TIADPAGVTTIHVERAEEMRDAVISRLPADIAVMVAAVADWRVTGSSEQKIKKQPGDAPP
ALQLTENPDILKTVGHHEKRPRVVVGFAAETQDVEKNGRAKLERKGADYIIANDVSAETG
IMGGDRNSVKIISADGVEAWPDLDKAEVAKRLAALIAEKLA