Protein Info for AMB_RS23255 in Magnetospirillum magneticum AMB-1

Annotation: adenylate/guanylate cyclase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 713 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 354 to 376 (23 residues), see Phobius details PF02743: dCache_1" amino acids 158 to 337 (180 residues), 76.6 bits, see alignment E=3.4e-25 PF00672: HAMP" amino acids 373 to 424 (52 residues), 24.2 bits, see alignment 5.4e-09 PF00211: Guanylate_cyc" amino acids 453 to 620 (168 residues), 65.1 bits, see alignment E=9.8e-22

Best Hits

KEGG orthology group: K01768, adenylate cyclase [EC: 4.6.1.1] (inferred from 100% identity to mag:amb1226)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W7Z5 at UniProt or InterPro

Protein Sequence (713 amino acids)

>AMB_RS23255 adenylate/guanylate cyclase domain-containing protein (Magnetospirillum magneticum AMB-1)
MPPKGFRIRLRVGITVMFLSVMLPLTALMTAVLYRQNSQLAIQLAEHAMDSATTDVVSGV
GSLLGPMGRVADLSVAFGKAEGDSIRRVEGLRPLVEALEKFPDIYALFFGFARDGAFYEV
IRVPPPGSGITLKGRNPPPNANYALRFIDTVDDERVDNWIYITHWGEVVGLERAAKATYD
PRNRPWYLAALKTNEIATSSLHVFSSIGRPGLTLSRQLATDDGQVIAVFGADLSIDTLSK
VLADHRIGDNGQVFILDEEGRLLGYPDPQRVLVQQGGHVEIAKAEEFSDPVLAGAVRKRA
AGAGDRFRATLGPDGDEYLVAFSRFPESFGKNWTIGVIAAEADFVGPLRKASGMILLIGA
GFLLLSSVAVVWASSLLTTPIRALTDEADRIRRLELDHDITVNSPVVEVQSLAAGLATMK
AALRSFGAYVPKGILRRIVESGTSTEIGGERRELTILFTDIKGFTRTSEDMAPEDVLHHL
SVYLEGMSGAIAAHNGTVDKFIGDAVMALWNAPQHDPDHVLHACRAMLACRAATAGLNAE
LIANNYPPMPTRYGLHTGMAVAGNVGCRDRMQYTALGAAVNLASRVESLNKHFGTEMLVT
GEVEDVVRDQFVLRPLGPVVASGTSIPILLFELVGALEGQPHAASPEDLARVARWREAFS
AYVDGDWARAAELFRAYGAVYSNDEAGRLLQARAAANAADPGHAEFAIQFAEK