Protein Info for AMB_RS19595 in Magnetospirillum magneticum AMB-1

Annotation: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 280 TIGR00965: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase" amino acids 6 to 279 (274 residues), 422.1 bits, see alignment E=4.8e-131 PF14805: THDPS_N_2" amino acids 6 to 71 (66 residues), 93 bits, see alignment E=1.6e-30 PF14602: Hexapep_2" amino acids 178 to 213 (36 residues), 49.8 bits, see alignment 3.3e-17 PF00132: Hexapep" amino acids 179 to 212 (34 residues), 27.3 bits, see alignment 3.1e-10

Best Hits

Swiss-Prot: 100% identical to DAPD_MAGSA: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD) from Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)

KEGG orthology group: K00674, 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase [EC: 2.3.1.117] (inferred from 100% identity to mag:amb3873)

MetaCyc: 69% identical to tetrahydrodipicolinate succinylase (Escherichia coli K-12 substr. MG1655)
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. [EC: 2.3.1.117]

Predicted SEED Role

"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117)" in subsystem Lysine Biosynthesis DAP Pathway (EC 2.3.1.117)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.117

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W0E8 at UniProt or InterPro

Protein Sequence (280 amino acids)

>AMB_RS19595 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (Magnetospirillum magneticum AMB-1)
MSFAALEKTIDAAWEARDGINLQTKGEVRDAVEAALDALDSGSLRVAAKGDDGKWVVNQW
LKKAVLLSFRLSDNKVMGDGPGTTWFDKVPTKFEGWDDSRFRAAGFRAVPGAVVRRSAYI
APGVVLMPSFVNLGAHVGSGTMVDTWATVGSCAQIGKNVHISGGAGIGGVLEPLQAGPVI
IEDNCFIGARAEVAEGVIVETGAVLSMGVYIGASTKIVDRETGEIFMGRVPAYSVVVSGT
MPGKPFPDGTPGPGLYCAVIVKRVDERTRSKVGINELLRD