Protein Info for AMB_RS11300 in Magnetospirillum magneticum AMB-1

Annotation: adenylate/guanylate cyclase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 684 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 315 to 332 (18 residues), see Phobius details amino acids 339 to 358 (20 residues), see Phobius details amino acids 364 to 382 (19 residues), see Phobius details PF05226: CHASE2" amino acids 14 to 329 (316 residues), 110.4 bits, see alignment E=1.2e-35 PF00211: Guanylate_cyc" amino acids 424 to 599 (176 residues), 97.5 bits, see alignment E=8e-32

Best Hits

KEGG orthology group: K01768, adenylate cyclase [EC: 4.6.1.1] (inferred from 100% identity to mag:amb2235)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q2W536 at UniProt or InterPro

Protein Sequence (684 amino acids)

>AMB_RS11300 adenylate/guanylate cyclase domain-containing protein (Magnetospirillum magneticum AMB-1)
MAKRYDILFTLILFLVAIPAQHFEWFALLEDQTLSFRHQLRLAYGDAKKLAVSPEVVVVN
TDEAFFKAYKSFPLRRTDIGTMVTNLKALGAKVIAVDMLMDFPSSYNEDPALAKALSDAG
NTVLVAQGEFRDGKFAKINYPTTLLDQASASAYTNIQSNSKLITSLSRLRVFPEMTAEKG
GWPFAVKAAAMYLGVEPRLDGTTLVLGELRVPLNHEHKLYIDFPPLPTGTRFLSQSAGLS
ALEFLDISGLDERELAELEYWVKDKIVVLGDTSEVSHDWFDTPVGMVYGVEIIADSISSI
LKGAPLRGAGPVMDSVAPVVLLLAMLLLSLYLTRPLLRGMFVVALGVGFIVSASALYVHL
GVVISMSYGVLALVLSYLLVEFRQYLIERNQKQQIAKTFGQYIPPELVAEMNKTGQQVTV
GGESREMTVLFSDVRGFTTISEGLAPQQLTVLMNAFLSPMTHVIHDFRGTIDKYMGDAIM
AFWGAPLHDPDHARHAVQAALGMVKKMEELKDDFVARGWKPIKVGIGLNTGIMNVGNMGS
DFRMAYTVLGDAVNLGSRVESLTKQYGVNMMVTEYTQAAVPGLISREIDLVRVKGKDTPV
RLYEPLGFEGEVDAETVARLSQHLAALAMFREQKWDAARMAFQELHNSDPERVIYKIYLG
RIEHFMEEPPGTDWDGVYTHKEKS