Protein Info for AMB_RS11185 in Magnetospirillum magneticum AMB-1

Annotation: nitrite/sulfite reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03460: NIR_SIR_ferr
  • amino acids 51 to 117 (67 residues), 55.8 bits, E=3.1e-19
  • amino acids 311 to 373 (63 residues), 34.3 bits, E=1.7e-12
• PF01077: NIR_SIR
  • amino acids 126 to 278 (153 residues), 128.9 bits, E=1.2e-41
  • amino acids 385 to 474 (90 residues), 27.9 bits, E=1.5e-10

Best Hits

KEGG orthology group: K00381, sulfite reductase (NADPH) hemoprotein beta-component [EC: 1.8.1.2] (inferred from 100% identity to mag:amb2209)

Predicted SEED Role

"Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2)" in subsystem Cysteine Biosynthesis (EC 1.8.1.2)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
• assimilatory sulfate reduction I (4/4 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (8/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.2

Sequence Analysis Tools

See Q2W562 at UniProt or InterPro

Protein Sequence (693 amino acids)

>AMB_RS11185 nitrite/sulfite reductase (Magnetospirillum magneticum AMB-1)
MKDASHVDLSAIEPLVRSSDLAEYRQGLERHQSGEWDAERFTAFRLRYGVYGQKQPGVQM
VRIKIPGGIVPTPWLKTLARVNRDFAKGPAHITTRQDFQLYYIPLERSADMLEVLAAGGI
TTREACGNTLRNMTSCALAGACGRELVDAGKVAEQLARTWMRHPLVQHMPRKMKFTVSGC
ATDCGASPIHDLGFVAVEKGGKKGFKVLAGGGLGGQPIMAVEVLPFVIEEDLPTVIEATA
RIHQRYSNRRDRALARLKFVLRRFGPEKFTSLFQEEFDRLKNLPQRPWQPLAWRNPVEAP
VARTPAGVVPGHDGKVALVIYVPLGIIDSDQLDALHDIAVAAGVSRLSTTRDQKLALLDV
ARDKVEEVTKAVRSIGFDIPAAAEDVPDVVSCPGTTTCRIGITNSQSFGLQVEKEARGQA
DAKGVSVHVSGCQNSCGLHHVADIGLHGMGKKIDGKPAPHYQLHFGGDAYSGQVGLEGPI
VPARLANRAVALLRQEIQGARAQGESVRAWAERLGKDGIAEVLKPLAAGEGEDLFTDWGD
ADIFVGPPKAKGECAAPQVSTTYYTDLADDGLINLDRFLSSGRWPEALKAGEEATVYALR
LLLAGYGVVTEDEQDAEGVFALFRSSKAATIEAVNAFESVLAERTSALVTGEAVTYREAV
AYFIDTVGVLITRPKAAVVAEVGDLASILAVVA