Protein Info for AMB_RS09340 in Magnetospirillum magneticum AMB-1

Annotation: CBS domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00291: PALP
  • amino acids 10 to 300 (291 residues), 246.8 bits, E=3.2e-77
• PF00571: CBS
  • amino acids 343 to 388 (46 residues), 33.8 bits, 3.5e-12
  • amino acids 398 to 450 (53 residues), 34.1 bits, 2.7e-12

Best Hits

KEGG orthology group: K01697, cystathionine beta-synthase [EC: 4.2.1.22] (inferred from 100% identity to mag:amb1847)

Predicted SEED Role

"Cystathionine beta-synthase (EC 4.2.1.22)" in subsystem Cysteine Biosynthesis or Glycine and Serine Utilization or Methionine Biosynthesis or Methionine Degradation (EC 4.2.1.22)

MetaCyc Pathways

• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (8/10 steps found)
• hydrogen sulfide biosynthesis II (mammalian) (4/6 steps found)
• superpathway of L-cysteine biosynthesis (fungi) (4/6 steps found)
• L-cysteine biosynthesis III (from L-homocysteine) (1/2 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (3/5 steps found)
• homocysteine and cysteine interconversion (2/4 steps found)
• taurine biosynthesis III (1/3 steps found)
• superpathway of L-methionine salvage and degradation (7/16 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Methionine metabolism
• Selenoamino acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.22

Sequence Analysis Tools

See Q2W674 at UniProt or InterPro

Protein Sequence (455 amino acids)

>AMB_RS09340 CBS domain-containing protein (Magnetospirillum magneticum AMB-1)
MPYDADLLCQIGNTPLIELTNLDTAPCRLFVKLESRNPSGSIKDRAALSMVRAAERDGLL
RPGGHLVEATAGNTGLALALLAAHRGYRLTLVIPDKAGLDKVSHLRAMGAEVVLARSDVP
RRHPEHYQNVASRLAGETGAHFIDQFNNPANPAAHEDGTGPELWEQMGGRVDAVVAGAGS
GGTLTGLSRFFARRSPATEMVLADPRGSVLADYVRTGRVGEAGSWLVEGIGGDSIPMVSD
FSRVTRAYSVSDRESFATARLVLRIEGLLVGSSSGTLLAAALRYCREQTAPKRVATLVCD
AGNRHLSRLHDESWLADQGLLQRDEHGDLRDLISRRHDEGAAITVRPDDTLSTAYNRMRV
NDVSQVPVVVGDRCIGLLDESDVLIALAEGKFGFDLPVRDAMTRKIETVTPQTPPERLLP
LFDRGWVAIVVDGERFLGLVTRMDLLNHLRRKLAA