Protein Info for AMB_RS06500 in Magnetospirillum magneticum AMB-1

Annotation: glutamine--fructose-6-phosphate transaminase (isomerizing)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 607 (606 residues), 812.4 bits, E=1.2e-248
• PF13522: GATase_6
  • amino acids 67 to 192 (126 residues), 76 bits, E=4.3e-25
• PF13537: GATase_7
  • amino acids 83 to 196 (114 residues), 54.2 bits, E=2.1e-18
• PF01380: SIS
  • amino acids 287 to 414 (128 residues), 107.5 bits, E=6.9e-35
  • amino acids 459 to 588 (130 residues), 74.4 bits, E=1.1e-24

Best Hits

Swiss-Prot: 60% identical to GLMS_ZYMMO: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 100% identity to mag:amb1279)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (5/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (3/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (7/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.16

Sequence Analysis Tools

See Q2W7U2 at UniProt or InterPro

Protein Sequence (607 amino acids)

>AMB_RS06500 glutamine--fructose-6-phosphate transaminase (isomerizing) (Magnetospirillum magneticum AMB-1)
MCGIVGIIGKVEAAPLLVEGLRRLEYRGYDSAGIATLVDGQIERRRAEGKLANLEALLKT
RPVGGLIGIGHTRWATHGVPNERNAHPHATKRVAVVHNGIIENFHELKAELSAKGQVFES
DTDTEAVAQLIDYHLAQGMGAEDATAKALERLQGAFALGIVFAGRPDMMIAARQGSPLAI
GYGAGEMYLGSDALALAPLTQKIAYLNDGDWAVLTAETVVIRDRTGATVTREVRQTQFSG
AMIGKGEHRHFMLKEIFEQPEVVSNALNTMLNPADRTITLPRLPFDLAAVKRVRIIACGT
SFYAGSVAKYWIEKLARLPVEVDIASEFRYRCPPMEADGLAIFISQSGETADTLAALRYC
REHGQHTLSLVNVPESTIARESEAALLTMAGPEIGVASTKAFTTQLTVLACLAIGMGRAT
GALSAEAEADICRSLSEIPARIAEVLRRDDDIRVIAQGIAEARDVLYLGRGTGYPIALEG
ALKLKEISYIHAEAYAAGELKHGPIALIDDSVPVIVICPTDELYEKTASNVQEVVARGGR
VVFFSDREGIDRLSAKVFSSMALPSVDPVVAPILYAIPVQLLAYHVAVAKGTDVDQPRNL
AKSVTVE