Protein Info for ABZR88_RS06685 in Mucilaginibacter yixingensis YX-36 DSM 26809

Annotation: cystathionine gamma-synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01053: Cys_Met_Meta_PP
  • amino acids 9 to 383 (375 residues), 516.7 bits, E=4.2e-159
• PF01041: DegT_DnrJ_EryC1
  • amino acids 55 to 177 (123 residues), 20.4 bits, E=4.2e-08
• PF00155: Aminotran_1_2
  • amino acids 55 to 183 (129 residues), 33.5 bits, E=4.1e-12

Best Hits

Swiss-Prot: 54% identical to METC_COXBU: Cystathionine beta-lyase (metC) from Coxiella burnetii (strain RSA 493 / Nine Mile phase I)

KEGG orthology group: K01758, cystathionine gamma-lyase [EC: 4.4.1.1] (inferred from 85% identity to phe:Phep_2908)

MetaCyc: 52% identical to cystathionine gamma-lyase (Helicobacter pylori 26695)
Cystathionine gamma-lyase. [EC: 4.4.1.1]

Predicted SEED Role

"Cystathionine gamma-lyase (EC 4.4.1.1)" in subsystem Cysteine Biosynthesis or Glycine and Serine Utilization or Methionine Biosynthesis or Methionine Degradation (EC 4.4.1.1)

MetaCyc Pathways

• superpathway of branched chain amino acid biosynthesis (17/17 steps found)
• superpathway of L-isoleucine biosynthesis I (13/13 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-isoleucine biosynthesis I (from threonine) (7/7 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (9/10 steps found)
• L-cysteine degradation II (3/3 steps found)
• L-serine degradation (3/3 steps found)
• L-methionine biosynthesis II (5/6 steps found)
• superpathway of L-cysteine biosynthesis (fungi) (5/6 steps found)
• L-cysteine biosynthesis III (from L-homocysteine) (2/2 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (4/5 steps found)
• homocysteine and cysteine interconversion (3/4 steps found)
• D-serine degradation (2/3 steps found)
• L-methionine degradation II (2/3 steps found)
• L-tryptophan degradation II (via pyruvate) (2/3 steps found)
• hydrogen sulfide biosynthesis II (mammalian) (4/6 steps found)
• glycine betaine degradation III (4/7 steps found)
• L-threonine degradation I (3/6 steps found)
• felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
• L-mimosine degradation (4/8 steps found)
• glycine betaine degradation I (4/8 steps found)
• superpathway of L-threonine metabolism (11/18 steps found)
• L-cysteine biosynthesis VI (reverse transsulfuration) (3/7 steps found)
• superpathway of L-methionine salvage and degradation (9/16 steps found)
• glutathione-mediated detoxification I (3/8 steps found)
• hypoglycin biosynthesis (3/14 steps found)
• purine nucleobases degradation II (anaerobic) (10/24 steps found)

KEGG Metabolic Maps

• Cysteine metabolism
• Glycine, serine and threonine metabolism
• Methionine metabolism
• Nitrogen metabolism
• Selenoamino acid metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.4.1.1

Use Curated BLAST to search for 4.4.1.1

Protein Sequence (384 amino acids)

>ABZR88_RS06685 cystathionine gamma-synthase (Mucilaginibacter yixingensis YX-36 DSM 26809)
MNNSKMKFATKAIHAGQHPDPTTGAVMTPIYQTSTYWQKSPGDNQGYEYSRGTNPTRKAL
EECLAALENAKHGLAFSSGMGATDAVMKLLQAGDEVIAGNDLYGGSYRIFTKIFANYGIK
FHFLDLSDPEIIRQYTNDKTKLVWIETPTNPTMQVVDIAAISKITKEKNLTLVVDNTFAS
PYLQNPMDLGADMVMHSVTKYIGGHSDVVMGALMMNDDDLYKRLWFIYNACGATPGPMDS
FLVLRGIKTLHLRMKAHCENGRKVAEFLKTHPKVEKIYWPGFTDHPNHEIAKQQMRDFGG
MISIVLKGADLQETFRIAGSFKVFTLAESLGGVESLINHPATMTHASIPKEVREAAGVVD
NLLRLSVGVEDVDDLLDDLKQALA