Protein Info for ABIE41_RS23655 in Bosea sp. OAE506

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 556 TIGR01228: urocanate hydratase" amino acids 9 to 551 (543 residues), 964.5 bits, see alignment E=7.8e-295 PF17391: Urocanase_N" amino acids 10 to 136 (127 residues), 196.2 bits, see alignment E=2.3e-62 PF01175: Urocanase" amino acids 139 to 347 (209 residues), 302.3 bits, see alignment E=2.7e-94 PF17392: Urocanase_C" amino acids 350 to 544 (195 residues), 309 bits, see alignment E=1.7e-96

Best Hits

Swiss-Prot: 83% identical to HUTU_ACICJ: Urocanate hydratase (hutU) from Acidiphilium cryptum (strain JF-5)

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 83% identity to amv:ACMV_17940)

MetaCyc: 78% identical to urocanase subunit (Pseudomonas putida)
Urocanate hydratase. [EC: 4.2.1.49]

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (556 amino acids)

>ABIE41_RS23655 urocanate hydratase (Bosea sp. OAE506)
MTRIDNSRVIRAPHGSELSAKSWLTEAPLRMLMNNLDPDVAEKPGELVVYGGIGRAARTW
EDFDRICASLRSLEADETLLVQSGKPVGIFRTHPDAPRVLIANSNLVPAYANWEHFHHLD
KLGLMMYGQMTAGSWIYIGTQGIVQGTYETFVEVGRQHYGGSLKGKWILTGGLGGMGGAQ
PLAATMAGASMIAVECKPSSIEFRLRTRYLDEKADSIDEALRIVEAAHAKGKAVSVGVLG
NAAEVFPDMVRRGIRPDVVTDQTSAHDPLNGYLPAGWTLEQWEERKERDPAGTIEAAKRS
MAEHVKAMLDFQRMGVPTLDYGNNIRQMAKDMGVANAFDFPGFVPAYIRPLFCRGIGPFR
WAALSGDPEDIYKTDAKVKELMPNDAHLHNWLDMARERIQFQGLPARICWVGLGDRHCLG
LAFNEMVAKGELKAPVVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNTAGG
ATWVSLHHGGGVGMGYSQHSGVVIVADGTPEAAKRLERVLWNDPATGVMRHADAGYEIAQ
DCAREKGLRLPGMGIG