Protein Info for ABIE41_RS23640 in Bosea sp. OAE506

Annotation: imidazolonepropionase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 410 TIGR01224: imidazolonepropionase" amino acids 35 to 410 (376 residues), 493.8 bits, see alignment E=1.5e-152 PF01979: Amidohydro_1" amino acids 70 to 387 (318 residues), 72.4 bits, see alignment E=4.2e-24 PF07969: Amidohydro_3" amino acids 117 to 388 (272 residues), 60.2 bits, see alignment E=2.7e-20

Best Hits

Swiss-Prot: 71% identical to HUTI_METS4: Imidazolonepropionase (hutI) from Methylobacterium sp. (strain 4-46)

KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 71% identity to met:M446_1654)

MetaCyc: 59% identical to imidazolonepropionase (Pseudomonas fluorescens)
Imidazolonepropionase. [EC: 3.5.2.7]

Predicted SEED Role

"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (410 amino acids)

>ABIE41_RS23640 imidazolonepropionase (Bosea sp. OAE506)
MATMSAETPTCDRLWTHARLATMAALAAAPYGAVEDGIVAARDGRILYAGPRKEAPAFAA
AETIDCGGRWITPGLIDCHTHLVYGGDRAHEFELRLQGASYEEIARAGGGILSTVTATRA
ASEDALFASADRRLSALLSEGVTTVEIKSGYGLEIEAEVKTLRVARRIGRERPVRVRTTF
LGAHAVPPEFKGRSGDYTALVAGPMLDAIAAEGLADAVDVFCEGIAFSPDETRAVFEAAQ
AKGLAIKIHAEQLSNLGGAALAASMGALSADHLEYLDQAGVNAMAKAGTVAVVLPGAFYF
LRETVKPPIALLRQHGVAIALATDANPGSSPLTSPLLVMNMACTLFRLTPEEALAGLTRH
AAQALGLSNEVGTLEAGKACDLAIWDIERPAELAYRIGFNPLHARIWNGQ