Protein Info for ABIE41_RS22500 in Bosea sp. OAE506

Annotation: murein biosynthesis integral membrane protein MurJ

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 508 transmembrane" amino acids 20 to 43 (24 residues), see Phobius details amino acids 86 to 104 (19 residues), see Phobius details amino acids 125 to 148 (24 residues), see Phobius details amino acids 157 to 179 (23 residues), see Phobius details amino acids 185 to 205 (21 residues), see Phobius details amino acids 226 to 255 (30 residues), see Phobius details amino acids 269 to 287 (19 residues), see Phobius details amino acids 307 to 330 (24 residues), see Phobius details amino acids 346 to 366 (21 residues), see Phobius details amino acids 378 to 398 (21 residues), see Phobius details amino acids 404 to 426 (23 residues), see Phobius details amino acids 438 to 461 (24 residues), see Phobius details amino acids 476 to 498 (23 residues), see Phobius details PF01943: Polysacc_synt" amino acids 2 to 291 (290 residues), 29.2 bits, see alignment E=9.9e-11 TIGR01695: murein biosynthesis integral membrane protein MurJ" amino acids 2 to 496 (495 residues), 364.1 bits, see alignment E=6.3e-113 PF03023: MurJ" amino acids 26 to 455 (430 residues), 341.1 bits, see alignment E=1.3e-105 PF01554: MatE" amino acids 232 to 395 (164 residues), 35.3 bits, see alignment E=1.4e-12

Best Hits

Swiss-Prot: 40% identical to MURJ_RHIME: Probable lipid II flippase MurJ (murJ) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K03980, virulence factor (inferred from 59% identity to mea:Mex_1p3511)

Predicted SEED Role

"Proposed peptidoglycan lipid II flippase MurJ" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (508 amino acids)

>ABIE41_RS22500 murein biosynthesis integral membrane protein MurJ (Bosea sp. OAE506)
MLRKILSVGGFTLLSRLSGFVRDIVLAAVLGAGAMMDAFSVALRLPNHFRAIFGEGAVNQ
AYIPAYARIRQQGGEAAAALFSNRVFSLNLIVQLVLVAIALPFMPEIVRLLAPGFANDPQ
RFDLAVSLTRITFPYLLFITLVTLLSANLNAVDRYAAAAAAPVLMNLCLIAALAVAFLFP
SAAYAAAWGMAVAGVLEWLLLAFAARRAGVAAALTRPRLDADVKSFFKAFGPAVIGSAGV
QIALFADTIIASLLPAGAYAALYYAERLYQLPIGVIAIGVGTVLLPTMSRLIAAGDEAGS
NRAQNRAIALTVVAAAPFAAAFLAIPELIVSALFERGRFDAAASQAAGAVLLAYAVGLPA
IVLIRTQVSTFQARGDTTTPMFVSLAAIGANVALKLLLWRDFGAAGLALATAAGAWINVA
TLFVLGIRRGWAKPDPRLGVLVSVTLAAALVAGVAARFAAPALLAATAGLPHEPRLVAVA
AVSVLAALLYAVVLAVGLKATGTVRLLR