Protein Info for ABIE41_RS15655 in Bosea sp. OAE506

Annotation: TolC family outer membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 465 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details TIGR01844: type I secretion outer membrane protein, TolC family" amino acids 32 to 444 (413 residues), 349.2 bits, see alignment E=1.7e-108 PF02321: OEP" amino acids 36 to 224 (189 residues), 128.7 bits, see alignment E=1.1e-41 amino acids 247 to 422 (176 residues), 107.1 bits, see alignment E=5.2e-35

Best Hits

KEGG orthology group: K12340, outer membrane channel protein TolC (inferred from 58% identity to mno:Mnod_6495)

Predicted SEED Role

"Type I secretion outer membrane protein, TolC precursor" in subsystem Multidrug Resistance Efflux Pumps or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (465 amino acids)

>ABIE41_RS15655 TolC family outer membrane protein (Bosea sp. OAE506)
MTRRNKNGTFGALTLAALGLVLASGVSPGAMAQTMEAALSRAYSGNPTLNAQRASLRATN
ENVPQALSGYRPRVTASADIGASITDANVPGGRTSTTRLAPRGGGVQVDQNIFDGGKTRN
SVGQAESQVLGARATLRNTEQNVLLDAATSYMNVLRDTAILTLNRNNVEVLEEQLRQTRD
RFQVGEVTRTDVAQAEARLSQSQSQAILAESNLKTSIARYRQNVGAEPKQLAPGKPVEHL
LPKSLPSALDSALSSHPAIVASLHGVDAAELQVKVTEADLYPVLGVRGLVQQRYDSTAFG
DNRASASVVGTLTIPIYEGGQVYSRTRQAKETAGQRRIEVDTQRDTVRAAVVSAWGGLEA
AKAQIVAAQAQVQAAETALAGVREEAKVGQRTTLDVLNAQQELVSARSTLVTAQRDRVVA
SYSVLSAIGRLSANTLRLKTEVYDERRHYEQVKGLLWGTETPDGR