Protein Info for ABIE41_RS14730 in Bosea sp. OAE506

Annotation: acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00289: Biotin_carb_N
  • amino acids 1 to 110 (110 residues), 154.8 bits, E=3.7e-49
• PF02786: CPSase_L_D2
  • amino acids 115 to 322 (208 residues), 270.6 bits, E=3e-84
• PF07478: Dala_Dala_lig_C
  • amino acids 144 to 291 (148 residues), 35.7 bits, E=2.3e-12
• PF02785: Biotin_carb_C
  • amino acids 336 to 447 (112 residues), 116.6 bits, E=2e-37
• PF18140: PCC_BT
  • amino acids 467 to 591 (125 residues), 111.1 bits, E=1.4e-35
• PF00364: Biotin_lipoyl
  • amino acids 602 to 664 (63 residues), 56 bits, E=1e-18

Best Hits

KEGG orthology group: K01965, propionyl-CoA carboxylase alpha chain [EC: 6.4.1.3] (inferred from 78% identity to mpo:Mpop_3181)

Predicted SEED Role

"Biotin carboxylase (EC 6.3.4.14) / Biotin carboxyl carrier protein" (EC 6.3.4.14)

MetaCyc Pathways

• biotin-carboxyl carrier protein assembly (4/4 steps found)
• propanoyl CoA degradation I (3/3 steps found)
• 3-hydroxypropanoate cycle (10/13 steps found)
• methylaspartate cycle (14/19 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (13/18 steps found)
• superpathway of the 3-hydroxypropanoate cycle (12/18 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (11/17 steps found)
• glyoxylate assimilation (8/13 steps found)
• superpathway of L-methionine salvage and degradation (7/16 steps found)
• mycolate biosynthesis (26/205 steps found)
• superpathway of mycolate biosynthesis (27/239 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis
• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.14, 6.4.1.3

Use Curated BLAST to search for 6.3.4.14 or 6.4.1.3

Protein Sequence (666 amino acids)

>ABIE41_RS14730 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha (Bosea sp. OAE506)
MFSKILIANRGEIACRVIKTARRMGIKTVAVYSDADRDALHVEMADEAVHIGPPAAAQSY
LVIEKIIAACKQTGAQAVHPGYGFLSEREAFAQALKDNGIVFIGPNPGAIAAMGDKIESK
KAAAAANVSTVPGFLGIIESPDHAVTIADEIGYPVMIKASAGGGGKGMRIAHSAGEVAEG
FARAKSEAASSFGDDRVFVEKFIVDPRHIEIQVLGDKHGNVIYLGERECSIQRRNQKVVE
EAPSPLLDEATRRKMGEQAVALAKAVNYDSAGTVEFVAGQDKSFFFLEMNTRLQVEHPVT
EMITGIDLVEEMIRVAYGEKLRLTQAEVKLNGWAVESRVYAEDPTRNFLPSTGRLVTYRP
PVEGPDGDAIVRNDTGVFEGGEISIYYDPMIAKLVTHAPTREAAIEAQGRALDAFAIDGI
RHNIPFVSALMHHPRWIAGNLSTGFIAEEFPEGFSLPVPEGEIALRLAAIAIACDHKLNQ
RKRAVSAQMEGWRRVAFDRTRVVLLGAERFEGQVGEQGGAVVIDFGSRSVTVASEWRPGQ
PVWNGTLDGVAIAAQIRPITNGFALGHAGAYADAVVRTPREAELAALMPEKVAADTGKVL
LCPMPGVVKAISVSVGQEVKAGEALCMVEAMKMENVLRAEKDATVAKILAKEGDSLAVDA
VIMEFA